BAIT
STAT3
1110034C02Rik, AW109958, Aprf, RP23-279L23.5
signal transducer and activator of transcription 3
GO Process (35)
GO Function (13)
GO Component (7)
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, ISO]
- astrocyte differentiation [IMP]
- cell proliferation [IDA]
- cellular response to hormone stimulus [ISO]
- cytokine-mediated signaling pathway [NAS]
- eating behavior [IMP]
- eye photoreceptor cell differentiation [IMP]
- glucose homeostasis [IMP]
- growth hormone receptor signaling pathway [ISO]
- interleukin-6-mediated signaling pathway [ISO]
- intracellular receptor signaling pathway [ISO]
- negative regulation of cell death [ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of glycolytic process [IMP]
- negative regulation of hydrogen peroxide biosynthetic process [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of neuron migration [IGI]
- phosphorylation [IDA]
- positive regulation of ATP biosynthetic process [ISO]
- positive regulation of Notch signaling pathway [IMP]
- positive regulation of growth factor dependent skeletal muscle satellite cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- protein import into nucleus [ISO]
- radial glial cell differentiation [IMP]
- regulation of mitochondrial membrane permeability [ISO]
- regulation of multicellular organism growth [IMP]
- regulation of transcription, DNA-templated [ISO, NAS]
- response to cytokine [ISO]
- response to estradiol [ISO]
- sexual reproduction [IMP]
- stem cell maintenance [IMP]
- temperature homeostasis [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function- CCR5 chemokine receptor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- glucocorticoid receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein dimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- CCR5 chemokine receptor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- glucocorticoid receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein dimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
IL6ST
5133400A03Rik, AA389424, BB405851, CD130, D13Ertd699e, gp130
interleukin 6 signal transducer
GO Process (20)
GO Function (12)
GO Component (12)
Gene Ontology Biological Process
- ciliary neurotrophic factor-mediated signaling pathway [ISO]
- cytokine-mediated signaling pathway [IDA, ISO]
- glycogen metabolic process [IMP]
- interleukin-27-mediated signaling pathway [ISO]
- interleukin-6-mediated signaling pathway [ISO]
- leukemia inhibitory factor signaling pathway [ISO]
- negative regulation of cytosolic calcium ion concentration [ISO]
- negative regulation of interleukin-6-mediated signaling pathway [ISO]
- oncostatin-M-mediated signaling pathway [ISO]
- positive regulation of T cell proliferation [ISO]
- positive regulation of astrocyte differentiation [IMP]
- positive regulation of cell proliferation [IGI, ISO]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of tyrosine phosphorylation of Stat1 protein [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISO]
- regulation of Notch signaling pathway [IDA]
- response to cytokine [ISO]
- signal transduction [IDA]
- triglyceride mobilization [ISO]
Gene Ontology Molecular Function- ciliary neurotrophic factor receptor activity [ISO]
- ciliary neurotrophic factor receptor binding [ISO]
- growth factor binding [ISO]
- interleukin-11 binding [IDA]
- interleukin-11 receptor activity [IDA]
- interleukin-6 binding [ISO]
- interleukin-6 receptor activity [ISO]
- interleukin-6 receptor binding [ISO]
- leukemia inhibitory factor receptor activity [ISO]
- oncostatin-M receptor activity [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- ciliary neurotrophic factor receptor activity [ISO]
- ciliary neurotrophic factor receptor binding [ISO]
- growth factor binding [ISO]
- interleukin-11 binding [IDA]
- interleukin-11 receptor activity [IDA]
- interleukin-6 binding [ISO]
- interleukin-6 receptor activity [ISO]
- interleukin-6 receptor binding [ISO]
- leukemia inhibitory factor receptor activity [ISO]
- oncostatin-M receptor activity [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
Gene Ontology Cellular Component
- cell body [IDA]
- ciliary neurotrophic factor receptor complex [ISO]
- cytosol [ISO]
- dendrite [IDA]
- external side of plasma membrane [IDA]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- interleukin-6 receptor complex [ISO]
- membrane [ISO]
- neuronal cell body [IDA]
- neuronal cell body membrane [ISO]
- oncostatin-M receptor complex [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.848 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID