BAIT
KALRN
2210407G14Rik, AV235988, DUET, E530005C20Rik, Gm539, Hapip, TRAD, RP23-363L9.1
kalirin, RhoGEF kinase
GO Process (4)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
LHCGR
Gpcr19-rs1, LH-R, Lhr
luteinizing hormone/choriogonadotropin receptor
GO Process (25)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP]
- activation of adenylate cyclase activity [IDA, ISO]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [ISO]
- arachidonic acid secretion [ISO]
- cellular response to gonadotropin stimulus [IDA]
- cognition [ISO]
- development of secondary male sexual characteristics [IMP]
- female gonad development [IMP]
- hormone-mediated signaling pathway [ISO]
- luteinizing hormone signaling pathway [ISO, TAS]
- male gonad development [IMP]
- ovarian follicle development [IMP]
- ovulation cycle process [IMP]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IDA, ISO]
- positive regulation of cAMP-mediated signaling [IDA]
- positive regulation of calcium ion transport into cytosol [ISO]
- positive regulation of calcium-mediated signaling [ISO]
- positive regulation of hormone biosynthetic process [ISO]
- positive regulation of inositol trisphosphate biosynthetic process [IDA]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- protein targeting to lysosome [ISO]
- regulation of steroid hormone biosynthetic process [IMP]
- seminiferous tubule development [IMP]
- spermatogenesis [IMP]
- uterus development [IMP]
Gene Ontology Molecular Function- ATPase binding [ISO]
- G-protein coupled peptide receptor activity [ISO]
- choriogonadotropin hormone binding [IDA]
- choriogonadotropin hormone receptor activity [IDA, IMP]
- identical protein binding [ISO]
- luteinizing hormone receptor activity [TAS]
- peptide hormone binding [ISO]
- protein homodimerization activity [ISO]
- ATPase binding [ISO]
- G-protein coupled peptide receptor activity [ISO]
- choriogonadotropin hormone binding [IDA]
- choriogonadotropin hormone receptor activity [IDA, IMP]
- identical protein binding [ISO]
- luteinizing hormone receptor activity [TAS]
- peptide hormone binding [ISO]
- protein homodimerization activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.729 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID