BAIT
LRP6
C030016K15Rik, Cd, Gw, ska26, ska, skax26
low density lipoprotein receptor-related protein 6
GO Process (91)
GO Function (13)
GO Component (12)
Gene Ontology Biological Process
- Wnt signaling pathway [IGI, ISO]
- Wnt signaling pathway involved in dorsal/ventral axis specification [IBA, ISO]
- Wnt signaling pathway involved in forebrain neuroblast division [IGI, IMP]
- Wnt signaling pathway involved in somitogenesis [IMP]
- anterior/posterior pattern specification [IGI, IMP]
- axis elongation [IMP]
- axis elongation involved in somitogenesis [IGI]
- bone morphogenesis [IMP]
- bone remodeling [IGI]
- branching involved in mammary gland duct morphogenesis [IMP]
- canonical Wnt signaling pathway [IGI, IMP, ISO]
- canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development [IMP]
- canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [IMP]
- cell migration involved in gastrulation [IGI]
- cellular response to cholesterol [ISO]
- cerebellum morphogenesis [IMP]
- cerebral cortex cell migration [IMP]
- cerebral cortex development [IMP]
- convergent extension [IGI]
- dopaminergic neuron differentiation [IMP]
- dorsal/ventral axis specification [IMP]
- embryonic camera-type eye morphogenesis [IMP]
- embryonic digit morphogenesis [IGI, IMP]
- embryonic forelimb morphogenesis [IGI, IMP]
- embryonic hindlimb morphogenesis [IGI, IMP]
- embryonic limb morphogenesis [IGI]
- embryonic pattern specification [IMP]
- embryonic retina morphogenesis in camera-type eye [IMP]
- external genitalia morphogenesis [IMP]
- face morphogenesis [IMP]
- forebrain development [IMP]
- forebrain generation of neurons [IMP]
- forebrain radial glial cell differentiation [IGI]
- formation of radial glial scaffolds [IGI]
- gastrulation with mouth forming second [IGI]
- generation of neurons [IMP]
- heart looping [IGI]
- limb morphogenesis [IGI, IMP]
- mammary gland duct morphogenesis [IGI]
- mammary placode formation [IMP]
- midbrain development [IMP]
- midbrain-hindbrain boundary development [IMP]
- morphogenesis of an epithelium [IMP]
- negative regulation of Wnt signaling pathway [IGI]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of non-canonical Wnt signaling pathway [IGI]
- negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [IGI]
- negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis [IGI]
- negative regulation of planar cell polarity pathway involved in neural tube closure [IGI]
- negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis [IGI]
- negative regulation of planar cell polarity pathway involved in pericardium morphogenesis [IGI]
- negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis [IGI]
- negative regulation of protein kinase activity [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of protein serine/threonine kinase activity [ISO]
- negative regulation of smooth muscle cell apoptotic process [ISO]
- neural crest cell differentiation [ISO]
- neural crest formation [IBA, ISO]
- neural tube closure [IGI, IMP]
- neural tube development [IGI]
- odontogenesis of dentin-containing tooth [IMP]
- palate development [IMP]
- pericardium morphogenesis [IGI]
- positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of bone resorption [IMP]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of cell cycle [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of ossification [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- post-anal tail morphogenesis [IGI, IMP]
- primitive streak formation [IGI]
- receptor-mediated endocytosis [IBA]
- receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [IMP]
- regulation of cell development [IMP]
- regulation of cell proliferation [IMP]
- regulation of transcription, DNA-templated [ISO]
- response to folic acid [IMP]
- retina morphogenesis in camera-type eye [IMP]
- single organismal cell-cell adhesion [ISO]
- skeletal system morphogenesis [IMP]
- somitogenesis [IGI]
- synaptic transmission [IBA, ISO]
- thalamus development [IMP]
- toxin transport [IMP, ISO]
- trachea cartilage morphogenesis [IGI]
Gene Ontology Molecular Function- Wnt-activated receptor activity [IBA]
- Wnt-protein binding [IPI, ISO]
- apolipoprotein binding [IPI]
- coreceptor activity [IBA]
- coreceptor activity involved in Wnt signaling pathway [ISO]
- frizzled binding [ISO]
- identical protein binding [ISO]
- kinase inhibitor activity [ISO]
- low-density lipoprotein receptor activity [IBA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
- toxin transporter activity [IMP]
- Wnt-activated receptor activity [IBA]
- Wnt-protein binding [IPI, ISO]
- apolipoprotein binding [IPI]
- coreceptor activity [IBA]
- coreceptor activity involved in Wnt signaling pathway [ISO]
- frizzled binding [ISO]
- identical protein binding [ISO]
- kinase inhibitor activity [ISO]
- low-density lipoprotein receptor activity [IBA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
- toxin transporter activity [IMP]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- caveola [IBA, ISO]
- cell [IMP]
- cell surface [IBA, ISO]
- cytoplasmic vesicle [ISO]
- cytosol [ISO]
- early endosome [IDA, ISO]
- membrane [IDA]
- neuronal cell body [IBA, ISO]
- plasma membrane [IDA, IGI, ISO]
- receptor complex [IBA]
- synapse [IBA, ISO]
Mus musculus
PREY
LRP4
6430526J12Rik, D230026E03, Megf7, mdig
low density lipoprotein receptor-related protein 4
GO Process (24)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- anatomical structure development [IMP]
- dendrite morphogenesis [ISO]
- dorsal/ventral pattern formation [IMP]
- embryonic digit morphogenesis [IMP]
- embryonic limb morphogenesis [IMP]
- hair follicle development [IMP]
- kidney development [IMP, ISO]
- limb development [ISO]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of axonogenesis [IMP]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of ossification [ISO]
- odontogenesis of dentin-containing tooth [IMP]
- positive regulation of presynaptic membrane organization [IDA]
- postsynaptic membrane assembly [IMP]
- presynaptic membrane assembly [IMP]
- protein heterotetramerization [ISO]
- protein localization [IMP]
- proximal/distal pattern formation [IMP]
- receptor clustering [IMP]
- regulation of protein phosphorylation [IMP]
- skeletal muscle acetylcholine-gated channel clustering [IMP]
- synapse organization [ISO]
- synaptic growth at neuromuscular junction [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.767 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID