BAIT
PID1
5033414K04Rik, NYGGF4
phosphotyrosine interaction domain containing 1
GO Process (21)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- cellular response to cytokine stimulus [IDA]
- cellular response to fatty acid [IDA]
- cellular response to interleukin-6 [IDA]
- cellular response to leptin stimulus [IDA]
- cellular response to tumor necrosis factor [IDA]
- mitochondrion morphogenesis [ISO]
- negative regulation of ATP biosynthetic process [ISO]
- negative regulation of establishment of protein localization to plasma membrane [ISO]
- negative regulation of glucose import [IMP]
- negative regulation of glucose import in response to insulin stimulus [ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of mitochondrial DNA replication [ISO]
- negative regulation of protein phosphorylation [ISO]
- positive regulation of ATP biosynthetic process [IMP]
- positive regulation of fat cell proliferation [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of G1/S transition of mitotic cell cycle [ISO]
- regulation of mitochondrial membrane potential [IMP]
- regulation of reactive oxygen species metabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [IDA, ISO]
- nucleoplasm [ISO]
Mus musculus
PREY
LRP4
6430526J12Rik, D230026E03, Megf7, mdig
low density lipoprotein receptor-related protein 4
GO Process (24)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- anatomical structure development [IMP]
- dendrite morphogenesis [ISO]
- dorsal/ventral pattern formation [IMP]
- embryonic digit morphogenesis [IMP]
- embryonic limb morphogenesis [IMP]
- hair follicle development [IMP]
- kidney development [IMP, ISO]
- limb development [ISO]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of axonogenesis [IMP]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of ossification [ISO]
- odontogenesis of dentin-containing tooth [IMP]
- positive regulation of presynaptic membrane organization [IDA]
- postsynaptic membrane assembly [IMP]
- presynaptic membrane assembly [IMP]
- protein heterotetramerization [ISO]
- protein localization [IMP]
- proximal/distal pattern formation [IMP]
- receptor clustering [IMP]
- regulation of protein phosphorylation [IMP]
- skeletal muscle acetylcholine-gated channel clustering [IMP]
- synapse organization [ISO]
- synaptic growth at neuromuscular junction [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.981 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID