BAIT
LRP4
6430526J12Rik, D230026E03, Megf7, mdig
low density lipoprotein receptor-related protein 4
GO Process (24)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- anatomical structure development [IMP]
- dendrite morphogenesis [ISO]
- dorsal/ventral pattern formation [IMP]
- embryonic digit morphogenesis [IMP]
- embryonic limb morphogenesis [IMP]
- hair follicle development [IMP]
- kidney development [IMP, ISO]
- limb development [ISO]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of axonogenesis [IMP]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of ossification [ISO]
- odontogenesis of dentin-containing tooth [IMP]
- positive regulation of presynaptic membrane organization [IDA]
- postsynaptic membrane assembly [IMP]
- presynaptic membrane assembly [IMP]
- protein heterotetramerization [ISO]
- protein localization [IMP]
- proximal/distal pattern formation [IMP]
- receptor clustering [IMP]
- regulation of protein phosphorylation [IMP]
- skeletal muscle acetylcholine-gated channel clustering [IMP]
- synapse organization [ISO]
- synaptic growth at neuromuscular junction [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
LRP5
BMND1, HBM, LR3, LRP7, OPPG, mKIAA4142
low density lipoprotein receptor-related protein 5
GO Process (47)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA, IGI, ISO]
- Wnt signaling pathway involved in dorsal/ventral axis specification [IBA, ISO]
- adipose tissue development [IBA, ISO]
- anatomical structure regression [IMP]
- anterior/posterior pattern specification [IGI]
- apoptotic process involved in patterning of blood vessels [IMP]
- bone development [IMP]
- bone marrow development [IBA, ISO]
- bone morphogenesis [IBA, ISO]
- bone remodeling [IGI, IMP]
- branching involved in mammary gland duct morphogenesis [IMP]
- canonical Wnt signaling pathway [IDA, IMP, ISO]
- cell migration involved in gastrulation [IGI]
- cell-cell signaling involved in mammary gland development [IMP]
- cholesterol homeostasis [IBA, ISO]
- cholesterol metabolic process [IMP]
- embryonic camera-type eye morphogenesis [IBA]
- embryonic digit morphogenesis [IGI]
- embryonic retina morphogenesis in camera-type eye [IBA]
- extracellular matrix-cell signaling [IDA]
- gastrulation with mouth forming second [IGI]
- glucose catabolic process [ISO]
- limb morphogenesis [IGI]
- mammary gland duct morphogenesis [IGI]
- negative regulation of osteoblast differentiation [ISO]
- negative regulation of protein serine/threonine kinase activity [ISO]
- osteoblast development [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of fat cell differentiation [ISO]
- positive regulation of mesenchymal cell proliferation [ISO]
- positive regulation of mitosis [ISO]
- positive regulation of osteoblast proliferation [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of apoptotic process [IMP]
- regulation of blood pressure [ISO]
- regulation of bone remodeling [IMP]
- regulation of canonical Wnt signaling pathway [ISO]
- regulation of fat cell differentiation [IBA]
- regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- regulation of ossification [IBA]
- retina morphogenesis in camera-type eye [ISO]
- retina vasculature morphogenesis in camera-type eye [IGI, IMP]
- retinal blood vessel morphogenesis [IBA, ISO]
- somatic stem cell maintenance [IMP]
- vasculature development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.699 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID