BAIT
DENND5A
1500012B19Rik, AJ245569, AW496491, ORF37, Rab6ip1, mKIAA1091
DENN/MADD domain containing 5A
GO Process (2)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MADD
9630059K23Rik, IG20, RP23-20F9.4
MAP-kinase activating death domain
GO Process (11)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
- activation of MAPK activity [IMP, ISO]
- execution phase of apoptosis [IMP, ISO]
- negative regulation of apoptotic signaling pathway [IMP]
- negative regulation of growth hormone secretion [ISO]
- negative regulation of pancreatic amylase secretion [ISO]
- positive regulation of Rab GTPase activity [IMP, ISO]
- regulation of Rab protein signal transduction [ISO]
- regulation of apoptotic process [ISO]
- regulation of cell cycle [IMP, ISO]
- regulation of extrinsic apoptotic signaling pathway [ISO]
- regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.914 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID