BAIT
TPM2
Tpm-2, Trop-2, RP23-195K8.10-003
tropomyosin 2, beta
GO Process (1)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NDRG2
AI182517, AU040374, Ndr2, SYLD
N-myc downstream regulated gene 2
GO Process (6)
GO Function (0)
GO Component (7)
Gene Ontology Biological Process
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of cytokine production [IMP]
- negative regulation of smooth muscle cell proliferation [IDA]
- regulation of platelet-derived growth factor production [IMP]
- regulation of vascular endothelial growth factor production [IMP]
- signal transduction [ISO]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.773 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID