BAIT
HIC1
ZBTB29, ZNF901, hic-1
hypermethylated in cancer 1
GO Process (5)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [ISS]
- regulation of transcription, DNA-templated [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
HIC1
ZBTB29, ZNF901, hic-1
hypermethylated in cancer 1
GO Process (5)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [ISS]
- regulation of transcription, DNA-templated [TAS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B.
Hypermethylated in cancer (HIC-1), a new candidate tumor suppressor gene located in 17p13.3, encodes a protein with five C(2)H(2) zinc fingers and an N-terminal broad complex, tramtrack, and bric a brac/poxviruses and zinc-finger (BTB/POZ) domain found in actin binding proteins or transcriptional regulators involved in chromatin modeling. In the human B cell lymphoma (BCL-6) and promyelocityc leukemia (PLZF) oncoproteins, this ... [more]
Proc. Natl. Acad. Sci. U.S.A. Dec. 21, 1999; 96(26);14831-6 [Pubmed: 10611298]
Throughput
- Low Throughput
Curated By
- BioGRID