BAIT
RGS2
GOS8, AL592303.1
regulator of G-protein signaling 2
GO Process (13)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- brown fat cell differentiation [IDA]
- negative regulation of G-protein coupled receptor protein signaling pathway [IMP, ISO]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of cAMP-mediated signaling [IMP]
- negative regulation of cardiac muscle hypertrophy [IMP]
- negative regulation of phospholipase activity [IMP]
- positive regulation of GTPase activity [IBA, ISO]
- positive regulation of cardiac muscle contraction [IMP]
- positive regulation of microtubule polymerization [ISO]
- regulation of adrenergic receptor signaling pathway [IMP]
- relaxation of cardiac muscle [IMP]
- relaxation of vascular smooth muscle [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NIPSNAP1
RP23-64E17.1
4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans)
GO Process (1)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.774 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID