BAIT
ATP2A2
9530097L16Rik, D5Wsu150e, SERCA2, SERCA2B, mKIAA4195
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
GO Process (22)
GO Function (9)
GO Component (13)
Gene Ontology Biological Process
- ATP catabolic process [IDA, ISO]
- ER-nucleus signaling pathway [IMP]
- T-tubule organization [IMP]
- calcium ion import into sarcoplasmic reticulum [ISO]
- calcium ion transmembrane transport [IDA, ISO]
- calcium ion transport [ISO]
- calcium ion transport from cytosol to endoplasmic reticulum [ISO]
- cellular calcium ion homeostasis [IDA, IGI, IMP, ISO]
- endoplasmic reticulum calcium ion homeostasis [ISO]
- negative regulation of heart contraction [IGI]
- organelle organization [IMP]
- positive regulation of endoplasmic reticulum calcium ion concentration [ISO]
- regulation of calcium ion-dependent exocytosis of neurotransmitter [IMP]
- regulation of cardiac muscle cell action potential involved in regulation of contraction [ISO]
- regulation of cardiac muscle cell membrane potential [ISO]
- regulation of cardiac muscle contraction by calcium ion signaling [ISO]
- regulation of muscle contraction [TAS]
- regulation of the force of heart contraction [IGI]
- relaxation of cardiac muscle [ISO]
- response to peptide hormone [ISO]
- sarcoplasmic reticulum calcium ion transport [IMP, ISO]
- transition between fast and slow fiber [IDA]
Gene Ontology Molecular Function- ATP binding [ISO]
- S100 protein binding [ISO]
- calcium ion binding [ISO]
- calcium-transporting ATPase activity [IDA, ISO]
- calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential [ISO]
- enzyme binding [IPI, ISO]
- lutropin-choriogonadotropic hormone receptor binding [ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
- ATP binding [ISO]
- S100 protein binding [ISO]
- calcium ion binding [ISO]
- calcium-transporting ATPase activity [IDA, ISO]
- calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential [ISO]
- enzyme binding [IPI, ISO]
- lutropin-choriogonadotropic hormone receptor binding [ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
Gene Ontology Cellular Component
- calcium ion-transporting ATPase complex [ISO]
- cell [IGI]
- endoplasmic reticulum [IDA, ISO]
- endoplasmic reticulum membrane [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [ISO]
- intercalated disc [ISO]
- longitudinal sarcoplasmic reticulum [ISO]
- membrane [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- protein complex [ISO]
- ribbon synapse [IDA]
- sarcoplasmic reticulum [IDA, ISO, TAS]
- vesicle membrane [ISO]
Mus musculus
PREY
NOS2
NOS-II, Nos-2, Nos2a, i-NOS, iNOS, RP23-341J22.2
nitric oxide synthase 2, inducible
GO Process (22)
GO Function (18)
GO Component (9)
Gene Ontology Biological Process
- arginine catabolic process [IDA, ISO]
- cellular response to interferon-gamma [IDA]
- cellular response to lipopolysaccharide [IDA]
- defense response to bacterium [IMP, ISO]
- inflammatory response [TAS]
- negative regulation of blood pressure [IBA]
- negative regulation of gene expression [IGI, ISO]
- negative regulation of protein catabolic process [IDA]
- nitric oxide biosynthetic process [IDA, ISO]
- nitric oxide mediated signal transduction [IBA]
- ovulation from ovarian follicle [IMP]
- oxidation-reduction process [IBA]
- peptidyl-cysteine S-nitrosylation [IDA]
- positive regulation of guanylate cyclase activity [IBA]
- positive regulation of killing of cells of other organism [ISO]
- positive regulation of vasodilation [IBA]
- regulation of cell proliferation [IGI]
- regulation of insulin secretion [ISO]
- regulation of protein kinase activity [ISO]
- response to hypoxia [IDA]
- response to lipopolysaccharide [IDA]
- superoxide metabolic process [IMP]
Gene Ontology Molecular Function- FMN binding [IDA]
- Hsp90 protein binding [ISO]
- NADPH-hemoprotein reductase activity [IBA]
- actin binding [ISO]
- arginine binding [IDA]
- beta-catenin binding [ISO]
- cAMP-dependent protein kinase regulator activity [ISO]
- cadherin binding [ISO]
- calmodulin binding [TAS]
- flavin adenine dinucleotide binding [IDA]
- heme binding [IDA]
- nitric-oxide synthase activity [IDA, ISO]
- nitric-oxide synthase binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA, ISO]
- protein kinase binding [ISO]
- receptor binding [ISO]
- tetrahydrobiopterin binding [IDA]
- FMN binding [IDA]
- Hsp90 protein binding [ISO]
- NADPH-hemoprotein reductase activity [IBA]
- actin binding [ISO]
- arginine binding [IDA]
- beta-catenin binding [ISO]
- cAMP-dependent protein kinase regulator activity [ISO]
- cadherin binding [ISO]
- calmodulin binding [TAS]
- flavin adenine dinucleotide binding [IDA]
- heme binding [IDA]
- nitric-oxide synthase activity [IDA, ISO]
- nitric-oxide synthase binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA, ISO]
- protein kinase binding [ISO]
- receptor binding [ISO]
- tetrahydrobiopterin binding [IDA]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.799 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID