BAIT
ETL4
6620402G01Rik, 9430077C05Rik, BC026657, E330027G05Rik, Etl-4, Skt, RP23-436G18.1
enhancer trap locus 4
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Mus musculus
PREY
NOS3
2310065A03Rik, Nos-3, eNOS, ecNOS
nitric oxide synthase 3, endothelial cell
GO Process (31)
GO Function (13)
GO Component (12)
Gene Ontology Biological Process
- angiogenesis [IMP]
- arginine catabolic process [ISO]
- blood vessel remodeling [IMP]
- cellular response to mechanical stimulus [ISO]
- cellular response to transforming growth factor beta stimulus [ISO]
- endothelial cell migration [ISO]
- in utero embryonic development [IMP]
- lipopolysaccharide-mediated signaling pathway [IMP]
- lung development [IMP]
- negative regulation of blood pressure [IBA]
- negative regulation of calcium ion transport [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of hydrolase activity [IMP]
- negative regulation of muscle hyperplasia [IMP]
- negative regulation of potassium ion transport [IMP]
- negative regulation of smooth muscle cell proliferation [ISO]
- nitric oxide biosynthetic process [IMP, ISO]
- nitric oxide mediated signal transduction [IBA]
- ovulation from ovarian follicle [IMP]
- oxidation-reduction process [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of guanylate cyclase activity [IBA, ISO]
- positive regulation of vasodilation [IBA]
- regulation of blood vessel size [IMP]
- regulation of sodium ion transport [IMP]
- regulation of systemic arterial blood pressure by endothelin [ISO]
- regulation of the force of heart contraction by chemical signal [IGI]
- response to estradiol [ISO]
- signal transduction [ISO]
- smooth muscle hyperplasia [IMP]
Gene Ontology Molecular Function- Hsp90 protein binding [ISO]
- NADPH-hemoprotein reductase activity [IBA]
- actin binding [ISO]
- actin monomer binding [ISO]
- arginine binding [ISO]
- beta-catenin binding [ISO]
- cadherin binding [ISO]
- calmodulin binding [ISO]
- heme binding [ISO]
- nitric-oxide synthase activity [IMP, ISO]
- nitric-oxide synthase binding [ISO]
- scaffold protein binding [ISO]
- tetrahydrobiopterin binding [ISO]
- Hsp90 protein binding [ISO]
- NADPH-hemoprotein reductase activity [IBA]
- actin binding [ISO]
- actin monomer binding [ISO]
- arginine binding [ISO]
- beta-catenin binding [ISO]
- cadherin binding [ISO]
- calmodulin binding [ISO]
- heme binding [ISO]
- nitric-oxide synthase activity [IMP, ISO]
- nitric-oxide synthase binding [ISO]
- scaffold protein binding [ISO]
- tetrahydrobiopterin binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.706 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID