BAIT
FGFR1
AW208770, Eask, FLG, Fgfr-1, Flt-2, Hspy, MFR, bFGF-R-1, c-fgr
fibroblast growth factor receptor 1
GO Process (41)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- angiogenesis [IGI]
- auditory receptor cell development [IMP]
- blood vessel morphogenesis [IMP]
- brain development [IMP]
- branching involved in salivary gland morphogenesis [IMP]
- cell maturation [IMP]
- chondrocyte differentiation [IGI]
- embryonic limb morphogenesis [IMP]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, ISO]
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [IMP]
- generation of neurons [IMP]
- in utero embryonic development [IGI]
- inner ear morphogenesis [IMP]
- lung development [IGI, IMP]
- lung-associated mesenchyme development [IGI]
- mesenchymal cell differentiation [IGI]
- midbrain development [IGI, IMP]
- middle ear morphogenesis [IMP]
- negative regulation of gene expression [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- orbitofrontal cortex development [IMP]
- organ induction [IMP]
- outer ear morphogenesis [IMP]
- paraxial mesoderm development [IGI]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [IGI]
- positive regulation of cardiac muscle cell proliferation [IGI]
- positive regulation of cell cycle [IMP]
- positive regulation of cell proliferation [IDA, IGI, IMP, ISO]
- positive regulation of mesenchymal cell proliferation [IGI, IMP]
- positive regulation of neuron projection development [IGI]
- regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [IDA]
- regulation of cell proliferation [IMP]
- regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- regulation of gene expression [IMP]
- regulation of lateral mesodermal cell fate specification [IGI]
- salivary gland morphogenesis [IMP]
- sensory perception of sound [IMP]
- ureteric bud development [IGI]
- vasculogenesis involved in coronary vascular morphogenesis [TAS]
- ventricular zone neuroblast division [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NTRK1
C80751, Tkr, TrkA, trk
neurotrophic tyrosine kinase, receptor, type 1
GO Process (31)
GO Function (9)
GO Component (12)
Gene Ontology Biological Process
- B cell differentiation [IMP]
- Sertoli cell development [ISO]
- axon guidance [ISO]
- axonogenesis involved in innervation [IMP]
- cellular response to growth factor stimulus [ISO]
- cellular response to nerve growth factor stimulus [ISO]
- cellular response to nicotine [ISO]
- detection of mechanical stimulus involved in sensory perception of pain [ISO]
- detection of temperature stimulus involved in sensory perception of pain [ISO]
- developmental programmed cell death [ISO]
- learning or memory [ISO]
- mechanoreceptor differentiation [IMP]
- negative regulation of neuron apoptotic process [IGI, IMP, ISO]
- negative regulation of neuron death [ISO]
- nerve growth factor signaling pathway [IGI, ISO]
- nervous system development [IDA]
- neurotrophin TRK receptor signaling pathway [ISO]
- peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of programmed cell death [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, ISO]
- response to activity [ISO]
- response to drug [ISO]
- response to electrical stimulus [ISO]
- response to nicotine [ISO]
- response to nutrient levels [ISO]
- sensory perception of pain [ISO]
- sympathetic nervous system development [IMP]
Gene Ontology Molecular Function- ephrin receptor binding [ISO]
- kinase binding [ISO]
- nerve growth factor binding [ISO]
- nerve growth factor receptor activity [ISO]
- neurotrophin p75 receptor binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein tyrosine kinase activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
- ephrin receptor binding [ISO]
- kinase binding [ISO]
- nerve growth factor binding [ISO]
- nerve growth factor receptor activity [ISO]
- neurotrophin p75 receptor binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein tyrosine kinase activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.959 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID