BAIT
CCT6B
CCT-zeta-2, CCTzeta-2, Cctz-2, TCP-1-zeta-2, RP23-316C11.1
chaperonin containing Tcp1, subunit 6b (zeta)
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Mus musculus
PREY
NUP62
AA589433, AI426861, AI790512, AU045898, D7Ertd649e, Nupc1, p62
nucleoporin 62
GO Process (13)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- cell aging [IDA]
- cell death [ISO]
- cell migration [NAS]
- cell surface receptor signaling pathway [ISO]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of Ras protein signal transduction [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of epidermal growth factor receptor signaling pathway [IMP]
- negative regulation of programmed cell death [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- transcription, DNA-templated [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.824 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID