BAIT
ARF6
AI788669, AW496366
ADP-ribosylation factor 6
GO Process (17)
GO Function (4)
GO Component (14)
Gene Ontology Biological Process
- GTP catabolic process [TAS]
- cortical actin cytoskeleton organization [ISO]
- establishment of epithelial cell polarity [IMP]
- hepatocyte apoptotic process [IMP]
- liver development [IMP]
- myeloid cell apoptotic process [IMP]
- negative regulation of dendrite development [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- protein localization to cell surface [IDA]
- protein localization to endosome [IMP, ISO]
- protein transport [TAS]
- regulation of Rac protein signal transduction [ISO]
- regulation of dendritic spine development [IMP, ISO]
- regulation of filopodium assembly [ISO]
- regulation of toll-like receptor 4 signaling pathway [NAS]
- ruffle organization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell cortex [ISO]
- cytoplasm [IDA]
- early endosome [ISO]
- endocytic vesicle [ISO]
- endosome [IDA, ISO, TAS]
- extracellular vesicular exosome [ISO]
- filopodium membrane [ISO]
- focal adhesion [ISO]
- membrane [ISO]
- myelin sheath [IDA]
- plasma membrane [IDA, ISO]
- recycling endosome [ISO]
- recycling endosome membrane [ISO]
- ruffle [ISO]
Mus musculus
PREY
PIP5K1A
PI4P5K-I[a], PIP5K1-alpha, PIP5KIalpha, Pipk5a
phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
GO Process (10)
GO Function (3)
GO Component (9)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- activation of Rac GTPase activity [ISO]
- cell chemotaxis [ISO]
- fibroblast migration [IMP]
- focal adhesion assembly [ISO]
- phosphatidylinositol metabolic process [IDA]
- phosphatidylinositol phosphorylation [IDA, ISO]
- phospholipid biosynthetic process [ISO]
- protein targeting to plasma membrane [ISO]
- ruffle assembly [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.897 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID