BAIT
PRDX2
AL022839, Band-8, NkefB, PRP, PrxII, TDX1, TPx, TPx-B, TR, TSA, Tdpx1, Torin
peroxiredoxin 2
GO Process (22)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- T cell proliferation [IMP]
- activation of MAPK activity [IMP]
- cellular response to oxidative stress [ISO]
- homeostasis of number of cells [IMP]
- hydrogen peroxide catabolic process [IMP]
- hydrogen peroxide metabolic process [IMP]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of T cell differentiation [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- negative regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of reactive oxygen species metabolic process [IMP]
- oxidation-reduction process [ISS]
- positive regulation of blood coagulation [IMP]
- regulation of apoptotic process [ISO]
- regulation of hydrogen peroxide metabolic process [IMP]
- removal of superoxide radicals [IMP, ISO]
- respiratory burst involved in inflammatory response [IMP]
- response to lipopolysaccharide [IMP]
- response to oxidative stress [ISO, TAS]
- thymus development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PPIF
AW457192, CyP-D, CyP-F, CypD, PPIase
peptidylprolyl isomerase F (cyclophilin F)
GO Process (20)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- apoptotic mitochondrial changes [IGI]
- cellular response to arsenic-containing substance [IMP]
- cellular response to calcium ion [IMP]
- cellular response to hydrogen peroxide [IMP, ISO]
- necroptotic process [IGI]
- negative regulation of ATPase activity [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [ISO]
- negative regulation of oxidative phosphorylation [IMP]
- negative regulation of oxidative phosphorylation uncoupler activity [IMP]
- negative regulation of release of cytochrome c from mitochondria [ISO]
- positive regulation of release of cytochrome c from mitochondria [IMP]
- protein peptidyl-prolyl isomerization [ISO, TAS]
- regulation of apoptotic process [ISO]
- regulation of mitochondrial membrane permeability [IGI, IMP, ISO]
- regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [IMP, ISO]
- regulation of necrotic cell death [IDA]
- regulation of proton-transporting ATPase activity, rotational mechanism [IMP]
- response to ischemia [IMP]
- response to oxidative stress [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.697 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID