BAIT
PTPRS
AL022616, PTP, PTP-NU3, PTPNU-3, PTPsigma, Ptpt9, R-PTP-S, RPTPsigma, AC073761.1
protein tyrosine phosphatase, receptor type, S
GO Process (6)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PTPN6
70Z-SHP, Hcph, PTPTY-42, Ptp1C, SH-PTP1, SHP-1, hcp, me
protein tyrosine phosphatase, non-receptor type 6
GO Process (29)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- B cell receptor signaling pathway [IMP]
- abortive mitotic cell cycle [IMP]
- cell differentiation [ISO]
- cell proliferation [ISO]
- cytokine-mediated signaling pathway [TAS]
- hematopoietic progenitor cell differentiation [IMP]
- intracellular signal transduction [IDA]
- megakaryocyte development [IMP]
- natural killer cell mediated cytotoxicity [IMP]
- negative regulation of B cell receptor signaling pathway [IGI]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of MAPK cascade [IMP]
- negative regulation of T cell proliferation [IMP]
- negative regulation of T cell receptor signaling pathway [IMP]
- negative regulation of humoral immune response mediated by circulating immunoglobulin [IMP]
- negative regulation of peptidyl-tyrosine phosphorylation [IMP, ISO]
- peptidyl-tyrosine dephosphorylation [IDA, ISO]
- peptidyl-tyrosine phosphorylation [ISO]
- platelet aggregation [IMP]
- platelet formation [IGI]
- positive regulation of cell adhesion mediated by integrin [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- protein dephosphorylation [IDA, IMP, ISO]
- regulation of B cell differentiation [IMP]
- regulation of ERK1 and ERK2 cascade [ISO]
- regulation of G1/S transition of mitotic cell cycle [ISO]
- regulation of release of sequestered calcium ion into cytosol [IGI]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.905 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID