BAIT
PTPRF
AA591035, LAR, LARS, RPTP-LAR, RP23-94L18.2
protein tyrosine phosphatase, receptor type, F
GO Process (20)
GO Function (8)
GO Component (9)
Gene Ontology Biological Process
- cell migration [ISO]
- homophilic cell adhesion via plasma membrane adhesion molecules [ISO]
- negative regulation of cell projection organization [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cytokine-mediated signaling pathway [ISO]
- negative regulation of epidermal growth factor receptor signaling pathway [ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of neurotrophin TRK receptor signaling pathway [ISO]
- negative regulation of receptor binding [ISO]
- nervous system development [ISO]
- neuron projection regeneration [IMP]
- peptidyl-tyrosine dephosphorylation [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of dendrite morphogenesis [ISO]
- positive regulation of neuron apoptotic process [ISO]
- protein dephosphorylation [ISO]
- regulation of axon regeneration [IMP]
- regulation of neuron projection development [IMP]
- regulation of synapse structure or activity [ISO]
- signal transduction [ISO]
Gene Ontology Molecular Function- chondroitin sulfate proteoglycan binding [IPI]
- insulin receptor binding [ISO]
- phosphate ion binding [ISO]
- phosphoprotein phosphatase activity [ISO]
- protein complex binding [IDA]
- protein tyrosine phosphatase activity [ISO]
- receptor tyrosine kinase binding [ISO]
- transmembrane receptor protein tyrosine phosphatase activity [ISO]
- chondroitin sulfate proteoglycan binding [IPI]
- insulin receptor binding [ISO]
- phosphate ion binding [ISO]
- phosphoprotein phosphatase activity [ISO]
- protein complex binding [IDA]
- protein tyrosine phosphatase activity [ISO]
- receptor tyrosine kinase binding [ISO]
- transmembrane receptor protein tyrosine phosphatase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
PTPRM
RPTPmu, mKIAA4044
protein tyrosine phosphatase, receptor type, M
GO Process (12)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- homophilic cell adhesion via plasma membrane adhesion molecules [ISO]
- negative regulation of angiogenesis [ISO]
- negative regulation of endothelial cell migration [ISO]
- negative regulation of endothelial cell proliferation [ISO]
- neuron projection development [ISO]
- peptidyl-tyrosine dephosphorylation [ISO]
- positive regulation of vasodilation [IMP]
- protein dephosphorylation [ISO]
- response to drug [ISO]
- retina layer formation [ISO]
- retinal ganglion cell axon guidance [ISO]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.905 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID