BAIT
EGLN1
AI503754, C1orf12, HIF-PH2, HPH-2, Hif-p4h-2, ORF13, Phd2, SM-20
egl-9 family hypoxia-inducible factor 1
GO Process (13)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- cardiac muscle tissue morphogenesis [IMP]
- heart trabecula formation [IMP]
- labyrinthine layer development [IMP]
- negative regulation of cAMP catabolic process [ISO]
- negative regulation of cyclic-nucleotide phosphodiesterase activity [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- oxidation-reduction process [ISO]
- oxygen homeostasis [ISO]
- peptidyl-proline hydroxylation to 4-hydroxy-L-proline [ISO]
- regulation of angiogenesis [IMP]
- response to hypoxia [ISO]
- response to nitric oxide [ISO]
- ventricular septum morphogenesis [IMP]
Gene Ontology Molecular Function- enzyme binding [ISO]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [ISO]
- peptidyl-proline 4-dioxygenase activity [ISO]
- peptidyl-proline dioxygenase activity [ISO]
- enzyme binding [ISO]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [ISO]
- peptidyl-proline 4-dioxygenase activity [ISO]
- peptidyl-proline dioxygenase activity [ISO]
Mus musculus
PREY
PYGL
liver glycogen phosphorylase
GO Process (2)
GO Function (2)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.897 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID