BAIT
ACVR2A
ActrIIa, Acvr2, TactrII, RP23-139F8.3
activin receptor IIA
GO Process (24)
GO Function (10)
GO Component (3)
Gene Ontology Biological Process
- BMP signaling pathway [IMP, ISO]
- Sertoli cell proliferation [IMP]
- activin receptor signaling pathway [ISO]
- anterior/posterior pattern specification [IGI]
- cellular response to BMP stimulus [ISO]
- determination of left/right symmetry [IGI]
- embryonic skeletal system development [IMP]
- gastrulation with mouth forming second [IGI]
- male gonad development [IMP]
- mesoderm development [IMP]
- penile erection [IMP]
- positive regulation of activin receptor signaling pathway [ISO]
- positive regulation of bone mineralization [ISO]
- positive regulation of erythrocyte differentiation [ISO]
- positive regulation of follicle-stimulating hormone secretion [ISO]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- positive regulation of protein phosphorylation [ISO]
- protein phosphorylation [ISO]
- regulation of BMP signaling pathway [IMP]
- regulation of nitric-oxide synthase activity [IMP]
- regulation of signal transduction [IDA]
- sperm ejaculation [IMP]
- spermatogenesis [IGI]
Gene Ontology Molecular Function- PDZ domain binding [IPI]
- activin binding [IPI, ISO]
- activin receptor activity, type II [ISO]
- activin-activated receptor activity [ISO]
- coreceptor activity [ISO]
- growth factor binding [IMP, IPI]
- inhibin binding [IPI, ISO]
- protein binding [IPI]
- protein self-association [IPI]
- protein serine/threonine kinase activity [ISO]
- PDZ domain binding [IPI]
- activin binding [IPI, ISO]
- activin receptor activity, type II [ISO]
- activin-activated receptor activity [ISO]
- coreceptor activity [ISO]
- growth factor binding [IMP, IPI]
- inhibin binding [IPI, ISO]
- protein binding [IPI]
- protein self-association [IPI]
- protein serine/threonine kinase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
REPS2
POB1, RP23-436I3.2
RALBP1 associated Eps domain containing protein 2
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.893 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID