BAIT
CACNA1A
APCA, BI, Caca1a, Cacnl1a4, Cav2.1, Ccha1a, EA2, FHM, HPCA, MHP, MHP1, SCA6, alpha1A, la, nmf352, rkr, tg
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
GO Process (50)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- adult walking behavior [IGI, IMP]
- behavioral response to pain [IMP]
- calcium ion import [IBA, ISO]
- calcium ion transmembrane transport [IGI]
- calcium ion transport [IMP, ISO]
- calcium ion-dependent exocytosis [IMP]
- calcium ion-dependent exocytosis of neurotransmitter [IMP]
- cell death [ISO]
- cell growth [IMP]
- cellular chloride ion homeostasis [IMP]
- central nervous system neuron differentiation [IMP]
- cerebellar Purkinje cell differentiation [IMP]
- cerebellar Purkinje cell layer development [IMP]
- cerebellar molecular layer development [IMP]
- cerebellum maturation [IMP]
- dendrite morphogenesis [IMP]
- gamma-aminobutyric acid secretion [IMP]
- gamma-aminobutyric acid signaling pathway [IMP]
- glucose metabolic process [IMP]
- hormone metabolic process [IMP]
- membrane depolarization [IMP]
- membrane depolarization during action potential [IBA]
- musculoskeletal movement, spinal reflex action [IMP]
- negative regulation of hormone biosynthetic process [IMP]
- negative regulation of neuron apoptotic process [IMP]
- neurological system process [IMP]
- neuromuscular process [IGI, IMP]
- neuromuscular process controlling balance [IMP]
- neuromuscular synaptic transmission [IMP]
- neuron-neuron synaptic transmission [IMP]
- neurotransmitter metabolic process [IMP]
- positive regulation of cytosolic calcium ion concentration [IDA, ISO]
- receptor clustering [IMP]
- regulation of acetylcholine secretion, neurotransmission [IMP]
- regulation of axonogenesis [IMP]
- regulation of calcium ion-dependent exocytosis [IDA]
- regulation of ion transmembrane transport [IGI]
- regulation of membrane potential [IMP]
- response to pain [IMP]
- rhythmic synaptic transmission [IMP]
- sensory perception of pain [ISO]
- spinal cord motor neuron differentiation [IMP]
- sulfur amino acid metabolic process [IMP]
- synapse assembly [IMP]
- synaptic transmission [IMP, ISO]
- synaptic transmission, GABAergic [IMP]
- synaptic transmission, glutamatergic [IMP]
- thyroid hormone metabolic process [IMP]
- transmission of nerve impulse [IMP]
- vestibular nucleus development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SCN5A
Nav1.5, Nav1.5c, SkM1, SkM2, mH1
sodium channel, voltage-gated, type V, alpha
GO Process (31)
GO Function (13)
GO Component (10)
Gene Ontology Biological Process
- AV node cell to bundle of His cell communication [ISO]
- SA node cell action potential [IMP]
- SA node cell to atrial cardiac muscle cell communication [ISO]
- bundle of His cell to Purkinje myocyte communication [ISO]
- cardiac muscle cell action potential involved in contraction [ISO]
- cardiac muscle contraction [ISO]
- cardiac ventricle development [IMP]
- cellular response to calcium ion [ISO]
- membrane depolarization [ISO]
- membrane depolarization during SA node cell action potential [IMP]
- membrane depolarization during action potential [ISO]
- membrane depolarization during cardiac muscle cell action potential [ISO]
- neuronal action potential [IBA]
- positive regulation of action potential [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of heart rate [ISO]
- positive regulation of sodium ion transport [ISO]
- regulation of atrial cardiac muscle cell membrane depolarization [ISO]
- regulation of atrial cardiac muscle cell membrane repolarization [ISO]
- regulation of cardiac muscle cell contraction [IMP, ISO]
- regulation of heart rate [ISO]
- regulation of heart rate by cardiac conduction [IMP, ISO]
- regulation of ion transmembrane transport [IMP]
- regulation of sodium ion transmembrane transport [ISO]
- regulation of ventricular cardiac muscle cell membrane depolarization [ISO]
- regulation of ventricular cardiac muscle cell membrane repolarization [ISO]
- response to denervation involved in regulation of muscle adaptation [ISO]
- response to organic cyclic compound [IMP]
- sodium ion transmembrane transport [IMP, ISO]
- sodium ion transport [IDA, ISO]
- ventricular cardiac muscle cell action potential [ISO]
Gene Ontology Molecular Function- ankyrin binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- fibroblast growth factor binding [ISO]
- ion channel binding [ISO]
- nitric-oxide synthase binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- scaffold protein binding [IPI, ISO]
- ubiquitin protein ligase binding [ISO]
- voltage-gated sodium channel activity [IDA, ISO]
- voltage-gated sodium channel activity involved in SA node cell action potential [IMP]
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential [IMP, ISO]
- ankyrin binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- fibroblast growth factor binding [ISO]
- ion channel binding [ISO]
- nitric-oxide synthase binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- scaffold protein binding [IPI, ISO]
- ubiquitin protein ligase binding [ISO]
- voltage-gated sodium channel activity [IDA, ISO]
- voltage-gated sodium channel activity involved in SA node cell action potential [IMP]
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential [IMP, ISO]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.898 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID