BAIT
SCN5A
Nav1.5, Nav1.5c, SkM1, SkM2, mH1
sodium channel, voltage-gated, type V, alpha
GO Process (31)
GO Function (13)
GO Component (10)
Gene Ontology Biological Process
- AV node cell to bundle of His cell communication [ISO]
- SA node cell action potential [IMP]
- SA node cell to atrial cardiac muscle cell communication [ISO]
- bundle of His cell to Purkinje myocyte communication [ISO]
- cardiac muscle cell action potential involved in contraction [ISO]
- cardiac muscle contraction [ISO]
- cardiac ventricle development [IMP]
- cellular response to calcium ion [ISO]
- membrane depolarization [ISO]
- membrane depolarization during SA node cell action potential [IMP]
- membrane depolarization during action potential [ISO]
- membrane depolarization during cardiac muscle cell action potential [ISO]
- neuronal action potential [IBA]
- positive regulation of action potential [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of heart rate [ISO]
- positive regulation of sodium ion transport [ISO]
- regulation of atrial cardiac muscle cell membrane depolarization [ISO]
- regulation of atrial cardiac muscle cell membrane repolarization [ISO]
- regulation of cardiac muscle cell contraction [IMP, ISO]
- regulation of heart rate [ISO]
- regulation of heart rate by cardiac conduction [IMP, ISO]
- regulation of ion transmembrane transport [IMP]
- regulation of sodium ion transmembrane transport [ISO]
- regulation of ventricular cardiac muscle cell membrane depolarization [ISO]
- regulation of ventricular cardiac muscle cell membrane repolarization [ISO]
- response to denervation involved in regulation of muscle adaptation [ISO]
- response to organic cyclic compound [IMP]
- sodium ion transmembrane transport [IMP, ISO]
- sodium ion transport [IDA, ISO]
- ventricular cardiac muscle cell action potential [ISO]
Gene Ontology Molecular Function- ankyrin binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- fibroblast growth factor binding [ISO]
- ion channel binding [ISO]
- nitric-oxide synthase binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- scaffold protein binding [IPI, ISO]
- ubiquitin protein ligase binding [ISO]
- voltage-gated sodium channel activity [IDA, ISO]
- voltage-gated sodium channel activity involved in SA node cell action potential [IMP]
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential [IMP, ISO]
- ankyrin binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- fibroblast growth factor binding [ISO]
- ion channel binding [ISO]
- nitric-oxide synthase binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- scaffold protein binding [IPI, ISO]
- ubiquitin protein ligase binding [ISO]
- voltage-gated sodium channel activity [IDA, ISO]
- voltage-gated sodium channel activity involved in SA node cell action potential [IMP]
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential [IMP, ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
SCN8A
AI853486, C630029C19Rik, NaCh6, Nav1.6, dmu, med, mnd-2, mnd2, nmf2, nmf335, nmf58, nur14, seal
sodium channel, voltage-gated, type VIII, alpha
GO Process (12)
GO Function (3)
GO Component (10)
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- adult walking behavior [IMP]
- locomotory behavior [IMP]
- membrane depolarization during action potential [IBA]
- muscle organ development [IMP]
- neuromuscular process [IMP]
- neuronal action potential [IBA, ISO]
- regulation of ion transmembrane transport [NAS]
- response to toxic substance [IDA]
- sensory perception of sound [IMP]
- sodium ion transmembrane transport [ISO, NAS]
- sodium ion transport [ISO, NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.881 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID