DMD
Gene Ontology Biological Process
- cardiac muscle cell action potential [IMP]
- cardiac muscle contraction [ISO]
- cellular protein complex assembly [IMP]
- cellular protein localization [IMP, ISO]
- establishment of blood-nerve barrier [IMP]
- establishment of glial blood-brain barrier [IMP]
- muscle cell cellular homeostasis [IMP]
- muscle fiber development [IGI]
- muscle organ development [IMP]
- myotube cell development [IMP]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of peptidyl-cysteine S-nitrosylation [IMP]
- negative regulation of peptidyl-serine phosphorylation [IMP]
- neurotransmitter receptor metabolic process [IMP]
- nucleus localization [IMP]
- olfactory nerve structural organization [IMP]
- peptide biosynthetic process [ISO]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of neuron differentiation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of sodium ion transmembrane transporter activity [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IMP]
- regulation of cellular response to growth factor stimulus [ISO]
- regulation of gene expression [IMP]
- regulation of heart rate [IMP, ISO]
- regulation of membrane potential [IMP]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IMP]
- regulation of ryanodine-sensitive calcium-release channel activity [IMP]
- regulation of skeletal muscle contraction [IMP]
- regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [IMP]
- regulation of transcription, DNA-templated [IMP]
- regulation of voltage-gated calcium channel activity [IMP]
- response to muscle stretch [IMP]
- skeletal muscle tissue development [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Z disc [IDA]
- cell [IMP]
- cell surface [ISO]
- cell-substrate junction [IDA]
- costamere [ISO]
- dystrophin-associated glycoprotein complex [IDA, ISO]
- filopodium [ISO]
- filopodium membrane [ISO]
- intracellular [IMP]
- membrane raft [IDA]
- neuron projection terminus [IDA]
- nucleus [ISO]
- plasma membrane [IDA]
- protein complex [ISO]
- sarcolemma [IDA, ISO]
- synapse [IDA]
SGCA
Gene Ontology Biological Process
Gene Ontology Cellular Component
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Quantitative Score
- 0.771 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
DMD SGCA | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID