BAIT
ARNT
D3Ertd557e, Drnt, ESTM42, Hif1b, W08714, bHLHe2, mKIAA4051
aryl hydrocarbon receptor nuclear translocator
GO Process (13)
GO Function (12)
GO Component (4)
Gene Ontology Biological Process
- cell differentiation [IMP]
- embryonic placenta development [IMP]
- intracellular receptor signaling pathway [IMP]
- positive regulation of hormone biosynthetic process [ISO]
- positive regulation of protein sumoylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation vascular endothelial growth factor production [ISO]
- regulation of nucleic acid-templated transcription [IPI]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [ISO]
- regulation of transcription, DNA-templated [TAS]
- response to hypoxia [IDA, ISO]
- response to toxic substance [TAS]
Gene Ontology Molecular Function- DNA binding [IGI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- aryl hydrocarbon receptor activity [IMP]
- aryl hydrocarbon receptor binding [ISO]
- enhancer binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [IDA]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [IPI]
- DNA binding [IGI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- aryl hydrocarbon receptor activity [IMP]
- aryl hydrocarbon receptor binding [ISO]
- enhancer binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [IDA]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [IPI]
Mus musculus
PREY
SIN3A
AW553200, Sin3, mKIAA4126, mSin3A
transcriptional regulator, SIN3A (yeast)
GO Process (26)
GO Function (14)
GO Component (10)
Gene Ontology Biological Process
- DNA replication [IMP]
- activation of innate immune response [ISO]
- aging [ISO]
- cellular protein localization [IMP]
- cellular response to glucose stimulus [IDA]
- hematopoietic progenitor cell differentiation [IMP]
- histone deacetylation [IBA]
- in utero embryonic development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of circadian rhythm [IMP]
- negative regulation of histone H3-K27 acetylation [ISO]
- negative regulation of protein localization to nucleus [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- negative regulation of transcription regulatory region DNA binding [ISO]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of chromatin silencing [ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein deacetylation [ISO]
- regulation of hormone levels [ISO]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [ISO]
- regulation of transcription, DNA-templated [IMP]
- response to methylglyoxal [IDA]
- response to organonitrogen compound [ISO]
- transcription from RNA polymerase II promoter [IGI]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II repressing transcription factor binding [IPI]
- RNA polymerase II transcription corepressor activity [IGI]
- chromatin binding [IDA]
- histone deacetylase activity [IBA]
- protein binding [IPI]
- protein complex binding [ISO]
- protein deacetylase activity [ISO]
- sequence-specific DNA binding transcription factor activity [IMP]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region sequence-specific DNA binding [IDA]
- DNA binding [IDA]
- RNA binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II repressing transcription factor binding [IPI]
- RNA polymerase II transcription corepressor activity [IGI]
- chromatin binding [IDA]
- histone deacetylase activity [IBA]
- protein binding [IPI]
- protein complex binding [ISO]
- protein deacetylase activity [ISO]
- sequence-specific DNA binding transcription factor activity [IMP]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.711 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID