BAIT
NPC1
A430089E03Rik, C85354, D18Ertd139e, D18Ertd723e, lcsd, nmf164, spm
Niemann-Pick type C1
GO Process (15)
GO Function (2)
GO Component (14)
Gene Ontology Biological Process
- adult walking behavior [IGI]
- autophagy [ISO]
- cellular response to low-density lipoprotein particle stimulus [IDA]
- cellular response to steroid hormone stimulus [IDA]
- cholesterol efflux [IMP, ISO]
- cholesterol homeostasis [ISO]
- cholesterol transport [ISO]
- endocytosis [IMP]
- establishment of protein localization to membrane [ISO]
- membrane raft organization [ISO]
- negative regulation of cell death [ISO]
- negative regulation of macroautophagy [IGI, IMP]
- protein glycosylation [IDA, ISO]
- response to cadmium ion [ISO]
- response to drug [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- endoplasmic reticulum [ISO]
- endosome [IDA]
- extracellular region [IDA]
- extracellular vesicular exosome [ISO]
- integral component of plasma membrane [ISO]
- lysosomal membrane [ISO]
- lysosome [IDA]
- membrane [IDA, ISO]
- membrane raft [IDA]
- nuclear envelope [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA]
- vesicle [IDA]
Mus musculus
PREY
SLC29A1
1200014D21Rik, AA407560, ENT1
solute carrier family 29 (nucleoside transporters), member 1
GO Process (5)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.772 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID