BAIT
PRKAR1B
AI385716, RIbeta
protein kinase, cAMP dependent regulatory, type I beta
GO Process (6)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SMAD4
AW743858, D18Wsu70e, DPC4, Madh4
SMAD family member 4
GO Process (54)
GO Function (23)
GO Component (10)
Gene Ontology Biological Process
- BMP signaling pathway [ISO]
- SMAD protein complex assembly [ISO]
- SMAD protein signal transduction [ISO]
- anterior/posterior pattern specification [IMP]
- atrioventricular canal development [IGI]
- atrioventricular valve formation [IGI]
- axon guidance [IMP]
- brainstem development [IMP]
- branching involved in ureteric bud morphogenesis [IGI]
- cardiac septum development [IGI]
- cell proliferation [IMP]
- developmental growth [IMP]
- endocardial cell differentiation [IMP]
- endoderm development [IMP]
- endothelial cell activation [IMP]
- epithelial to mesenchymal transition involved in endocardial cushion formation [IMP]
- formation of anatomical boundary [IMP]
- gastrulation [IMP]
- gastrulation with mouth forming second [IMP]
- in utero embryonic development [IMP]
- intracellular signal transduction [ISO]
- kidney development [IMP]
- mesoderm development [IMP]
- metanephric mesenchyme morphogenesis [IMP]
- negative regulation of cell death [IMP]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of protein catabolic process [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- nephrogenic mesenchyme morphogenesis [IMP]
- neural crest cell differentiation [IMP]
- neuron fate commitment [IMP]
- palate development [IMP]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of SMAD protein import into nucleus [IMP]
- positive regulation of cell proliferation involved in heart valve morphogenesis [IMP]
- positive regulation of epithelial to mesenchymal transition [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISO]
- regulation of binding [IDA]
- regulation of cell proliferation [IGI, IMP]
- regulation of hair follicle development [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transforming growth factor beta receptor signaling pathway [ISO]
- regulation of transforming growth factor beta2 production [ISO]
- response to hypoxia [ISO]
- response to transforming growth factor beta [ISO]
- sebaceous gland development [IMP]
- somite rostral/caudal axis specification [IMP]
- tissue morphogenesis [IMP]
- transcription from RNA polymerase II promoter [ISO]
- transforming growth factor beta receptor signaling pathway [IGI, ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding [IPI]
- RNA polymerase II transcription factor binding transcription factor activity [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [ISO]
- chromatin binding [IDA]
- collagen binding [IPI]
- core promoter proximal region sequence-specific DNA binding [ISO]
- filamin binding [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein binding transcription factor activity [ISO]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor, common-partner cytoplasmic mediator activity [ISO]
- DNA binding [IDA, ISO]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding [IPI]
- RNA polymerase II transcription factor binding transcription factor activity [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [ISO]
- chromatin binding [IDA]
- collagen binding [IPI]
- core promoter proximal region sequence-specific DNA binding [ISO]
- filamin binding [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein binding transcription factor activity [ISO]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor, common-partner cytoplasmic mediator activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.75 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID