BAIT
ROCK1
1110055K06Rik, Rock-I
Rho-associated coiled-coil containing protein kinase 1
GO Process (16)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- Rho protein signal transduction [ISO]
- actin cytoskeleton organization [IGI]
- apical constriction [IGI]
- bleb assembly [IMP]
- cytoskeleton organization [ISO]
- leukocyte cell-cell adhesion [ISO]
- leukocyte migration [ISO]
- leukocyte tethering or rolling [ISO]
- membrane to membrane docking [ISO]
- myoblast migration [IMP]
- negative regulation of angiogenesis [ISO]
- negative regulation of neuron apoptotic process [IMP]
- positive regulation of focal adhesion assembly [IMP]
- protein phosphorylation [ISO]
- regulation of actin filament-based process [IGI]
- regulation of keratinocyte differentiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SMC6
2810489L22Rik, 3830418C19Rik, AA990493, AU018782, AW742439, SMC-6, Smc6l1, mKIAA4103
structural maintenance of chromosomes 6
GO Process (2)
GO Function (0)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.771 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID