BAIT
KMT2B
2610014H22Rik, Mll2, Wbp7, mKIAA0304
lysine (K)-specific methyltransferase 2B
GO Process (9)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SMO
E130215L21Rik, Smoh, bnb, smoothened
smoothened homolog (Drosophila)
GO Process (67)
GO Function (4)
GO Component (15)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IBA]
- anterior/posterior pattern specification [IMP]
- astrocyte activation [IMP]
- atrial septum morphogenesis [IGI]
- axon extension involved in axon guidance [ISO]
- cell development [IMP]
- cell fate specification [IMP]
- central nervous system development [IGI]
- central nervous system neuron differentiation [IMP]
- cerebellar cortex morphogenesis [IMP]
- cerebral cortex development [IMP]
- detection of cell density by contact stimulus involved in contact inhibition [ISO]
- determination of left/right asymmetry in lateral mesoderm [IMP]
- determination of left/right symmetry [IMP]
- developmental growth [IMP]
- digestive tract development [IMP]
- dorsal/ventral neural tube patterning [IMP]
- dorsal/ventral pattern formation [IMP]
- embryonic organ development [IGI]
- epithelial-mesenchymal cell signaling [IMP]
- forebrain morphogenesis [IMP]
- hair follicle morphogenesis [IMP]
- heart looping [IMP]
- heart morphogenesis [IGI]
- homeostasis of number of cells within a tissue [IDA]
- in utero embryonic development [IMP]
- mammary gland epithelial cell differentiation [IMP]
- mesenchymal to epithelial transition involved in metanephric renal vesicle formation [IMP]
- midgut development [IMP]
- multicellular organism growth [IGI, IMP]
- myoblast migration [IGI]
- negative regulation of DNA binding [IGI, IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of epithelial cell differentiation [IMP]
- negative regulation of gene expression [IMP]
- negative regulation of hair follicle development [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- neural crest cell migration [IGI]
- odontogenesis of dentin-containing tooth [IMP]
- ossification [IMP]
- osteoblast differentiation [IMP]
- pancreas morphogenesis [IMP]
- pattern specification process [IMP]
- positive regulation of branching involved in ureteric bud morphogenesis [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of hh target transcription factor activity [IMP]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of neuroblast proliferation [IGI]
- positive regulation of protein import into nucleus [IGI]
- positive regulation of smoothened signaling pathway [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein localization to nucleus [IMP]
- protein stabilization [IDA]
- regulation of gene expression [IGI]
- regulation of heart morphogenesis [IMP]
- regulation of stem cell maintenance [IMP]
- skeletal muscle fiber development [IMP]
- smoothened signaling pathway [IGI, IMP, ISO]
- smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation [IMP]
- smoothened signaling pathway involved in ventral spinal cord patterning [IMP]
- somite development [IMP]
- thalamus development [IMP]
- type B pancreatic cell development [IMP]
- vasculogenesis [IMP]
- ventral midline determination [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- axonal growth cone [ISO]
- caveola [ISO]
- ciliary membrane [IDA]
- cilium [IDA]
- cytoplasm [IDA, ISO]
- dendrite [ISO]
- dendritic growth cone [ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [IBA]
- intracellular membrane-bounded organelle [ISO]
- neuronal cell body [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [ISO]
- primary cilium [IDA]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.842 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID