BAIT
SORT1
2900053A11Rik, AI852375, Ntr3, Ntsr3, RP23-27B23.3
sortilin 1
GO Process (16)
GO Function (5)
GO Component (13)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- Golgi to endosome transport [ISO]
- endocytosis [ISO]
- endosome to lysosome transport [ISO]
- endosome transport via multivesicular body sorting pathway [ISO]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- glucose import [IMP, ISO]
- myotube differentiation [IMP, ISO]
- negative regulation of lipoprotein lipase activity [ISO]
- nerve growth factor signaling pathway [ISO]
- neuropeptide signaling pathway [ISO]
- neurotrophin TRK receptor signaling pathway [ISO]
- plasma membrane to endosome transport [ISO]
- regulation of gene expression [ISO]
- response to insulin [IMP, ISO]
- vesicle organization [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- cell surface [ISO]
- clathrin-coated vesicle [ISO]
- coated pit [ISO]
- cytoplasmic membrane-bounded vesicle [ISO]
- dendrite [ISO]
- early endosome [ISO]
- integral component of membrane [ISO]
- intracellular membrane-bounded organelle [ISO]
- neuronal cell body [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- trans-Golgi network transport vesicle [IDA]
Mus musculus
PREY
SORCS2
N28137, mKIAA1329
sortilin-related VPS10 domain containing receptor 2
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.955 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID