BAIT
CSF1R
AI323359, CD115, CSF-1R, Csfmr, Fim-2, Fms, M-CSF-R, M-CSFR
colony stimulating factor 1 receptor
GO Process (27)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- cell proliferation [ISO]
- cell-cell junction maintenance [ISO]
- cellular response to cytokine stimulus [IMP]
- cellular response to macrophage colony-stimulating factor stimulus [IMP, ISO]
- cytokine-mediated signaling pathway [ISO]
- hemopoiesis [ISO]
- macrophage colony-stimulating factor signaling pathway [IMP]
- osteoclast differentiation [IMP]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- phosphatidylinositol metabolic process [IMP]
- phosphatidylinositol-mediated signaling [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell motility [ISO]
- positive regulation of cell proliferation [IMP, ISO]
- positive regulation of chemokine secretion [ISO]
- positive regulation of osteoclast differentiation [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein serine/threonine kinase activity [IMP]
- positive regulation of protein tyrosine kinase activity [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IMP]
- protein autophosphorylation [IDA, ISO]
- regulation of actin cytoskeleton reorganization [IMP]
- regulation of bone resorption [ISO]
- regulation of cell shape [IMP, ISO]
- ruffle organization [IMP]
- transmembrane receptor protein tyrosine kinase signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SOS1
4430401P03Rik, 9630010N06, AI449023
son of sevenless homolog 1 (Drosophila)
GO Process (11)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- B cell homeostasis [IGI]
- Ras protein signal transduction [ISO]
- fibroblast growth factor receptor signaling pathway [IGI]
- lymphocyte homeostasis [IGI]
- neurotrophin TRK receptor signaling pathway [ISO]
- positive regulation of Ras GTPase activity [IMP, ISO]
- positive regulation of small GTPase mediated signal transduction [ISO]
- regulation of T cell differentiation in thymus [IGI]
- regulation of T cell proliferation [IGI]
- regulation of pro-B cell differentiation [IGI]
- small GTPase mediated signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.781 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID