BAIT
SLC7A2
20.5, AI158848, Atrc2, CAT-2, Cat2, Tea
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
GO Process (14)
GO Function (8)
GO Component (1)
Gene Ontology Biological Process
- L-alpha-amino acid transmembrane transport [IMP]
- L-arginine import across plasma membrane [IDA]
- L-arginine transport [IMP]
- L-lysine import across plasma membrane [IDA]
- L-ornithine import across plasma membrane [IDA]
- L-ornithine transmembrane transport [IDA]
- amino acid transmembrane transport [ISO]
- arginine transport [ISO]
- cation transmembrane transport [IMP]
- macrophage activation [IMP]
- nitric oxide biosynthetic process [IMP]
- nitric oxide production involved in inflammatory response [IMP]
- regulation of inflammatory response [IMP]
- regulation of macrophage activation [IMP]
Gene Ontology Molecular Function- L-arginine transmembrane transporter activity [IMP]
- L-lysine transmembrane transporter activity [IDA]
- L-ornithine transmembrane transporter activity [IDA]
- arginine transmembrane transporter activity [IMP, ISO]
- high-affinity L-ornithine transmembrane transporter activity [IDA]
- high-affinity arginine transmembrane transporter activity [IDA]
- high-affinity lysine transmembrane transporter activity [IDA]
- low-affinity L-arginine transmembrane transporter activity [IDA]
- L-arginine transmembrane transporter activity [IMP]
- L-lysine transmembrane transporter activity [IDA]
- L-ornithine transmembrane transporter activity [IDA]
- arginine transmembrane transporter activity [IMP, ISO]
- high-affinity L-ornithine transmembrane transporter activity [IDA]
- high-affinity arginine transmembrane transporter activity [IDA]
- high-affinity lysine transmembrane transporter activity [IDA]
- low-affinity L-arginine transmembrane transporter activity [IDA]
Gene Ontology Cellular Component
Mus musculus
PREY
SRGAP2
9930124L22Rik, AI448945, FBP2, Fnbp2, srGAP3
SLIT-ROBO Rho GTPase activating protein 2
GO Process (10)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- actin filament severing [ISO]
- dendritic spine development [IMP, ISO]
- extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration [IMP]
- filopodium assembly [IDA, ISO]
- lamellipodium assembly involved in ameboidal cell migration [ISO]
- negative regulation of cell migration [IBA]
- negative regulation of neuron migration [ISO]
- neuron projection morphogenesis [IMP]
- positive regulation of Rac GTPase activity [IDA, ISO]
- substrate adhesion-dependent cell spreading [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.811 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID