BAIT
WNK4
2010002J11Rik, Pha2b, Prkwnk4, RP23-281C18.8
WNK lysine deficient protein kinase 4
GO Process (10)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- cellular chloride ion homeostasis [TAS]
- chloride transport [IDA]
- distal tubule morphogenesis [ISO]
- ion homeostasis [ISO]
- ion transport [IDA]
- negative regulation of pancreatic juice secretion [IMP]
- protein localization [IDA]
- protein phosphorylation [ISO]
- regulation of cellular process [IDA]
- renal sodium ion absorption [ISO]
Gene Ontology Molecular Function
Mus musculus
PREY
STK39
AW227544, AW556857, DCHT, RF005, Rnl5, SPAK, RP23-27J1.4
serine/threonine kinase 39
GO Process (14)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- intracellular signal transduction [IBA, ISO]
- negative regulation of potassium ion transmembrane transport [IDA, ISO]
- negative regulation of potassium ion transmembrane transporter activity [ISO]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of rubidium ion transmembrane transporter activity [ISO]
- negative regulation of rubidium ion transport [ISO]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of potassium ion transport [ISO]
- protein phosphorylation [IBA, ISO]
- regulation of blood pressure [IMP]
- regulation of inflammatory response [IDA]
- regulation of ion homeostasis [IMP]
- signal transduction by phosphorylation [IBA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.985 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID