BAIT
STRN
AU022939, D130055P19
striatin, calmodulin binding protein
GO Process (4)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
STK4
AI447339, AU020804, Kas-2, Mst1, Ysk3, RP23-346D16.3
serine/threonine kinase 4
GO Process (24)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
- apoptotic process [ISO]
- cell differentiation involved in embryonic placenta development [IGI]
- cell morphogenesis [ISO]
- central nervous system development [IGI]
- endocardium development [IGI]
- hepatocyte apoptotic process [IGI]
- hippo signaling [IGI, IMP, ISO]
- intracellular signal transduction [IBA, ISO]
- keratinocyte differentiation [IGI]
- negative regulation of canonical Wnt signaling pathway [IGI, ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of organ growth [IGI]
- neural tube formation [IGI]
- patterning of blood vessels [IGI]
- peptidyl-serine phosphorylation [ISO]
- positive regulation of apoptotic process [IGI, ISO]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [IGI]
- positive regulation of fat cell differentiation [ISO]
- positive regulation of protein binding [ISO]
- primitive hemopoiesis [IGI]
- protein autophosphorylation [ISO]
- protein phosphorylation [IBA, ISO]
- response to stress [IBA]
- signal transduction by phosphorylation [IBA]
Gene Ontology Molecular Function- ATP binding [ISO]
- identical protein binding [ISO]
- magnesium ion binding [ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activity [ISO]
- receptor signaling protein serine/threonine kinase activity [IBA]
- transcription factor binding [ISO]
- ATP binding [ISO]
- identical protein binding [ISO]
- magnesium ion binding [ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activity [ISO]
- receptor signaling protein serine/threonine kinase activity [IBA]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- cytoplasm [IDA, ISO]
- intracellular [IGI]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.881 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID