BAIT
NEDD4
AA959633, AL023035, AU019897, E430025J12Rik, Nedd4-1, Nedd4a, mKIAA0093
neural precursor cell expressed, developmentally down-regulated 4
GO Process (16)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- T cell activation [IMP]
- adaptive immune response [IMP]
- blood vessel morphogenesis [IGI, IMP]
- endocardial cushion development [IGI, IMP]
- negative regulation of sodium ion transport [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- neuromuscular junction development [IMP]
- outflow tract morphogenesis [IGI, IMP]
- positive regulation of protein catabolic process [IDA, ISO]
- protein K63-linked ubiquitination [ISO]
- protein monoubiquitination [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA, IMP]
- regulation of dendrite morphogenesis [IMP, ISO]
- regulation of synapse organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SULF1
AI467640, AW121680, mKIAA1077
sulfatase 1
GO Process (22)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- bone development [IGI]
- cartilage development [IMP]
- chondrocyte development [IMP]
- embryonic skeletal system development [IGI]
- esophagus smooth muscle contraction [IGI]
- glial cell-derived neurotrophic factor receptor signaling pathway [IDA]
- glomerular basement membrane development [IGI]
- glomerular filtration [IGI]
- heparan sulfate proteoglycan metabolic process [IMP, ISO]
- innervation [IGI]
- kidney development [IGI]
- negative regulation of angiogenesis [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of endothelial cell proliferation [ISO]
- negative regulation of fibroblast growth factor receptor signaling pathway [IDA, IGI, ISO]
- negative regulation of prostatic bud formation [IDA]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of Wnt signaling pathway [ISO]
- positive regulation vascular endothelial growth factor production [IGI]
- regulation of fibroblast growth factor receptor signaling pathway [ISO]
- sulfur compound metabolic process [ISO]
- vascular endothelial growth factor receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.853 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID