BAIT
SYNGAP1
Gm1963, Syngap
synaptic Ras GTPase activating protein 1 homolog (rat)
GO Process (14)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- Ras protein signal transduction [IDA]
- dendrite development [IMP]
- negative regulation of Ras protein signal transduction [IBA, ISO]
- negative regulation of axonogenesis [IDA]
- negative regulation of neuron apoptotic process [IMP]
- pattern specification process [IMP]
- positive regulation of Rab GTPase activity [IDA]
- positive regulation of Ras GTPase activity [IBA, ISO]
- receptor clustering [IMP]
- regulation of MAPK cascade [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI, IMP]
- regulation of synapse structure or activity [IMP]
- regulation of synaptic plasticity [ISO]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SYNE2
6820443O06Rik, AW546258, D12Ertd777e, NUA, Nesp2g, mKIAA1011
spectrin repeat containing, nuclear envelope 2
GO Process (9)
GO Function (1)
GO Component (17)
Gene Ontology Biological Process
- centrosome localization [IMP, ISO]
- cytoskeletal anchoring at nuclear membrane [ISO]
- establishment or maintenance of cell polarity [IMP]
- fibroblast migration [IMP]
- nuclear envelope organization [IMP]
- nuclear migration [ISO]
- nuclear migration along microfilament [IMP]
- positive regulation of cell migration [IMP]
- protein localization to nucleus [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SUN-KASH complex [ISO]
- Z disc [IDA, ISO]
- aggresome [ISO]
- cytoplasm [ISO]
- extracellular vesicular exosome [ISO]
- filopodium membrane [ISO]
- focal adhesion [ISO]
- intermediate filament cytoskeleton [ISO]
- lamellipodium membrane [ISO]
- mitochondrion [ISO]
- myofibril [IDA]
- nuclear envelope [IDA, IMP, ISO]
- nuclear lumen [ISO]
- nuclear membrane [IDA, ISO]
- nuclear outer membrane [IDA]
- nucleus [ISO]
- sarcoplasmic reticulum [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.839 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID