BAIT
EPS8
AW261790
epidermal growth factor receptor pathway substrate 8
GO Process (12)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- Rac protein signal transduction [IDA]
- actin crosslink formation [IDA, IMP]
- actin cytoskeleton reorganization [IMP]
- actin filament bundle assembly [IDA, IGI, IMP]
- actin polymerization-dependent cell motility [IDA]
- adult locomotory behavior [IMP]
- barbed-end actin filament capping [IDA, IMP]
- behavioral response to ethanol [IMP]
- dendritic cell migration [IMP]
- exit from mitosis [IMP]
- regulation of actin filament length [IMP]
- regulation of cell shape [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TBK1
1200008B05Rik, AI462036, AW048562
TANK-binding kinase 1
GO Process (8)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- activation of innate immune response [IMP]
- defense response to Gram-positive bacterium [IMP]
- dendritic cell proliferation [IGI]
- negative regulation of gene expression [IMP]
- positive regulation of interferon-alpha production [ISO]
- positive regulation of interferon-beta biosynthetic process [IMP]
- positive regulation of interferon-beta production [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.791 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID