BAIT
THRA
6430529J03Rik, AW259572, Erba, Nr1a1, Rvr, T3R[a], T3Ralpha, Thra1, Thra2, RP23-395E10.6
thyroid hormone receptor alpha
GO Process (25)
GO Function (20)
GO Component (4)
Gene Ontology Biological Process
- Type I pneumocyte differentiation [IGI]
- cartilage condensation [IMP]
- cytoplasmic sequestering of transcription factor [IDA]
- erythrocyte differentiation [IMP]
- female courtship behavior [IMP]
- hormone-mediated signaling pathway [ISO]
- intracellular receptor signaling pathway [IDA]
- learning or memory [IMP]
- negative regulation of DNA-templated transcription, initiation [ISO]
- negative regulation of RNA polymerase II transcriptional preinitiation complex assembly [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- organ morphogenesis [IMP]
- ossification [IMP]
- positive regulation of female receptivity [IMP]
- positive regulation of myotube differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- regulation of heart contraction [IMP]
- regulation of lipid catabolic process [IMP]
- regulation of myeloid cell apoptotic process [IMP]
- regulation of thyroid hormone mediated signaling pathway [IMP]
- regulation of transcription from RNA polymerase II promoter [ISO, TAS]
- response to cold [IMP]
- thyroid gland development [IGI]
- transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- TBP-class protein binding [ISO]
- chromatin DNA binding [IDA]
- intronic transcription regulatory region DNA binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein complex binding [IDA]
- protein dimerization activity [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- single-stranded RNA binding [IDA, ISO]
- steroid receptor RNA activator RNA binding [IDA]
- thyroid hormone binding [ISO]
- thyroid hormone receptor activity [ISO, TAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- TBP-class protein binding [ISO]
- chromatin DNA binding [IDA]
- intronic transcription regulatory region DNA binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein complex binding [IDA]
- protein dimerization activity [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- single-stranded RNA binding [IDA, ISO]
- steroid receptor RNA activator RNA binding [IDA]
- thyroid hormone binding [ISO]
- thyroid hormone receptor activity [ISO, TAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Mus musculus
PREY
TBL1X
5330429M20, Tbl1, RP23-238B14.2
transducin (beta)-like 1 X-linked
GO Process (13)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- canonical Wnt signaling pathway [ISO]
- fat cell differentiation [IMP]
- histone deacetylation [IBA]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- proteolysis [ISO]
- regulation of transcription from RNA polymerase II promoter [IGI]
- response to estrogen [IMP]
- response to steroid hormone [IMP]
- sensory perception of sound [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- beta-catenin binding [ISO]
- chromatin binding [IDA]
- histone binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- transcription corepressor activity [IMP, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
- DNA binding [IDA]
- beta-catenin binding [ISO]
- chromatin binding [IDA]
- histone binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- transcription corepressor activity [IMP, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.854 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID