BAIT
ARNT
D3Ertd557e, Drnt, ESTM42, Hif1b, W08714, bHLHe2, mKIAA4051
aryl hydrocarbon receptor nuclear translocator
GO Process (13)
GO Function (12)
GO Component (4)
Gene Ontology Biological Process
- cell differentiation [IMP]
- embryonic placenta development [IMP]
- intracellular receptor signaling pathway [IMP]
- positive regulation of hormone biosynthetic process [ISO]
- positive regulation of protein sumoylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation vascular endothelial growth factor production [ISO]
- regulation of nucleic acid-templated transcription [IPI]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [ISO]
- regulation of transcription, DNA-templated [TAS]
- response to hypoxia [IDA, ISO]
- response to toxic substance [TAS]
Gene Ontology Molecular Function- DNA binding [IGI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- aryl hydrocarbon receptor activity [IMP]
- aryl hydrocarbon receptor binding [ISO]
- enhancer binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [IDA]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [IPI]
- DNA binding [IGI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- aryl hydrocarbon receptor activity [IMP]
- aryl hydrocarbon receptor binding [ISO]
- enhancer binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [IDA]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [IPI]
Mus musculus
PREY
TCF7L2
TCF4B, TCF4E, Tcf-4, Tcf4, mTcf-4B, mTcf-4E
transcription factor 7 like 2, T cell specific, HMG box
GO Process (63)
GO Function (15)
GO Component (10)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA, IGI]
- blood vessel development [ISO]
- bone mineralization [IGI]
- canonical Wnt signaling pathway [IMP]
- canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition [ISO]
- catenin import into nucleus [IDA]
- cell cycle arrest [ISO]
- cell proliferation [ISO]
- cellular glucose homeostasis [IMP]
- cellular response to starvation [IMP]
- embryonic digestive tract morphogenesis [IGI]
- embryonic genitalia morphogenesis [IGI]
- embryonic hindgut morphogenesis [IGI]
- face morphogenesis [IGI]
- fat cell differentiation [ISO]
- glucose homeostasis [IMP, ISO]
- glucose metabolic process [IMP]
- glycogen metabolic process [IMP]
- insulin metabolic process [IMP]
- maintenance of DNA repeat elements [ISO]
- multicellular organism growth [IMP]
- myoblast fate commitment [IMP, ISO]
- negative regulation of BMP signaling pathway [IMP]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of fibroblast growth factor receptor signaling pathway [IMP]
- negative regulation of organ growth [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of type B pancreatic cell apoptotic process [ISO]
- neural tube development [IGI]
- odontogenesis of dentin-containing tooth [IGI]
- oligodendrocyte development [IMP]
- pituitary gland development [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of gluconeogenesis [IMP]
- positive regulation of heparan sulfate proteoglycan biosynthetic process [ISO]
- positive regulation of insulin secretion [IMP, ISO]
- positive regulation of lipid biosynthetic process [IMP]
- positive regulation of protein binding [ISO]
- positive regulation of protein export from nucleus [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of triglyceride biosynthetic process [IMP]
- post-embryonic development [IMP]
- regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of hormone metabolic process [ISO]
- regulation of insulin secretion involved in cellular response to glucose stimulus [IMP, ISO]
- regulation of myelination [IMP]
- regulation of oligodendrocyte differentiation [IMP]
- regulation of skeletal muscle tissue development [IMP]
- regulation of smooth muscle cell proliferation [ISO]
- regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- regulation of transcription, DNA-templated [IBA, IDA]
- response to glucose [IMP]
- secretory granule localization [IMP]
- skin development [IGI]
- somatic stem cell maintenance [IGI, IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [ISO]
- armadillo repeat domain binding [ISO]
- beta-catenin binding [IDA, IPI, ISO]
- chromatin binding [IDA, IGI]
- gamma-catenin binding [ISO]
- nuclear hormone receptor binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IBA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [ISO]
- armadillo repeat domain binding [ISO]
- beta-catenin binding [IDA, IPI, ISO]
- chromatin binding [IDA, IGI]
- gamma-catenin binding [ISO]
- nuclear hormone receptor binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IBA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.722 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID