BAIT
RNF216
2810055G22Rik, AI647468, AU019462, C86502, F830018F18Rik, TRIAD3, UIP83, Ubce7ip1
ring finger protein 216
GO Process (4)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Mus musculus
PREY
TIRAP
AA407980, C130027E04Rik, Mal, Tlr4ap, Wyatt
toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
GO Process (35)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA stabilization [ISO]
- I-kappaB kinase/NF-kappaB signaling [IMP, ISO]
- TIRAP-dependent toll-like receptor 4 signaling pathway [ISO]
- activation of JUN kinase activity [ISO]
- cell surface receptor signaling pathway [IPI, ISO]
- cellular response to bacterial lipopeptide [IMP]
- cellular response to lipoteichoic acid [IMP]
- defense response to Gram-positive bacterium [IMP]
- interleukin-1-mediated signaling pathway [IDA, NAS]
- myeloid cell differentiation [IMP]
- negative regulation of growth of symbiont in host [IMP]
- positive regulation of B cell proliferation [IMP]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of NF-kappaB transcription factor activity [IMP, ISO]
- positive regulation of chemokine (C-X-C motif) ligand 1 production [IMP]
- positive regulation of chemokine (C-X-C motif) ligand 2 production [IMP]
- positive regulation of innate immune response [IMP]
- positive regulation of interleukin-12 production [IMP]
- positive regulation of interleukin-15 production [ISO]
- positive regulation of interleukin-6 biosynthetic process [IDA, IMP, ISO]
- positive regulation of interleukin-8 production [IMP, ISO]
- positive regulation of neutrophil chemotaxis [IMP]
- positive regulation of protein homodimerization activity [ISO]
- positive regulation of toll-like receptor 2 signaling pathway [ISO]
- positive regulation of toll-like receptor 3 signaling pathway [IDA]
- positive regulation of toll-like receptor 4 signaling pathway [ISO]
- positive regulation of tumor necrosis factor production [IMP, ISO]
- regulation of innate immune response [NAS]
- regulation of interferon-beta production [IDA]
- regulation of interleukin-15 production [IMP]
- response to bacterium [ISO]
- response to lipopolysaccharide [ISO]
- toll-like receptor 5 signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.936 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID