BAIT
IL1B
IL-1beta, Il-1b, RP23-384K11.2
interleukin 1 beta
GO Process (79)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- MAPK cascade [ISO]
- activation of MAPK activity [ISO]
- aging [ISO]
- cellular response to drug [ISO]
- cellular response to organic cyclic compound [ISO]
- cellular response to organic substance [ISO]
- cytokine-mediated signaling pathway [IBA, ISO]
- ectopic germ cell programmed cell death [IGI]
- extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- hyaluronan biosynthetic process [ISO]
- inflammatory response [ISO]
- interleukin-1 beta production [IGI]
- leukocyte migration [IDA]
- lipopolysaccharide-mediated signaling pathway [ISO]
- memory [ISO]
- monocyte aggregation [ISO]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of adiponectin secretion [IDA]
- negative regulation of branching morphogenesis of a nerve [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of glucose transport [IDA]
- negative regulation of glutamate secretion [ISO]
- negative regulation of insulin receptor signaling pathway [IDA]
- negative regulation of lipid catabolic process [ISO]
- negative regulation of lipid metabolic process [IDA]
- negative regulation of neural precursor cell proliferation [ISO]
- negative regulation of neurogenesis [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- neutrophil chemotaxis [IDA]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA, IGI, ISO]
- positive regulation of JNK cascade [IDA, IGI, ISO]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of NF-kappaB import into nucleus [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of T cell proliferation [ISO]
- positive regulation of angiogenesis [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of astrocyte differentiation [ISO]
- positive regulation of calcidiol 1-monooxygenase activity [ISO]
- positive regulation of cell death [ISO]
- positive regulation of chemokine biosynthetic process [IDA]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of fever generation [IDA]
- positive regulation of gene expression [IDA, ISO]
- positive regulation of glial cell differentiation [ISO]
- positive regulation of granulocyte macrophage colony-stimulating factor production [ISO]
- positive regulation of heterotypic cell-cell adhesion [ISO]
- positive regulation of immature T cell proliferation in thymus [ISO]
- positive regulation of interferon-gamma production [ISO]
- positive regulation of interleukin-2 biosynthetic process [ISO]
- positive regulation of interleukin-6 biosynthetic process [IDA]
- positive regulation of interleukin-6 production [IDA, ISO]
- positive regulation of interleukin-8 production [ISO]
- positive regulation of lipid catabolic process [IDA]
- positive regulation of membrane protein ectodomain proteolysis [ISO]
- positive regulation of mitosis [ISO]
- positive regulation of monocyte chemotactic protein-1 production [ISO]
- positive regulation of myosin light chain kinase activity [ISO]
- positive regulation of neutrophil chemotaxis [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of prostaglandin secretion [IDA]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of stress-activated MAPK cascade [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation vascular endothelial growth factor production [IMP, ISO]
- protein kinase B signaling [ISO]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- regulation of insulin secretion [ISO]
- response to ATP [IDA, IMP]
- response to carbohydrate [IDA]
- response to lipopolysaccharide [IDA, IMP]
- sequestering of triglyceride [ISO]
- social behavior [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TRAF3
AI528849, CAP-1, CD40bp, CRAF1, LAP1, T-BAM, amn
TNF receptor-associated factor 3
GO Process (7)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- negative regulation of NF-kappaB transcription factor activity [IMP, ISO, TAS]
- regulation of cytokine production [IMP]
- regulation of defense response to virus [IMP]
- regulation of interferon-beta production [IMP]
- regulation of proteolysis [IDA, IMP, ISO]
- toll-like receptor signaling pathway [IMP]
- tumor necrosis factor-mediated signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.967 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID