BAIT
PIH1D1
1110061L23Rik, 4933413A04Rik, Nop17
PIH1 domain containing 1
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Mus musculus
PREY
TSC1
RP23-362N19.3
tuberous sclerosis 1
GO Process (33)
GO Function (5)
GO Component (12)
Gene Ontology Biological Process
- activation of Rho GTPase activity [ISO]
- cardiac muscle cell differentiation [IMP]
- cell projection organization [IMP]
- cell-matrix adhesion [ISO]
- cerebral cortex development [IMP]
- embryo development [IMP]
- glucose import [IMP]
- hippocampus development [IMP]
- kidney development [IMP]
- myelination [IMP]
- negative regulation of TOR signaling [IBA, ISO]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of cell size [IGI, IMP]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of translation [ISO]
- nervous system development [IMP]
- neural tube closure [IMP]
- positive regulation of focal adhesion assembly [ISO]
- potassium ion transport [IGI, IMP]
- protein heterooligomerization [ISO]
- protein stabilization [ISO]
- rRNA export from nucleus [ISO]
- regulation of Ras GTPase activity [IBA]
- regulation of actin cytoskeleton organization [IBA, ISO]
- regulation of cell cycle [IBA]
- regulation of cell-matrix adhesion [ISO]
- regulation of focal adhesion assembly [ISO]
- regulation of phosphoprotein phosphatase activity [ISO]
- regulation of protein kinase activity [IGI]
- regulation of stress fiber assembly [ISO]
- regulation of translation [ISO]
- response to insulin [ISO]
- synapse organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.806 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID