BAIT
PRKCI
2310021H13Rik, AI427505, PKClambda, Pkci, Pkcl, Prkcl, aPKClambda, mKIAA4165
protein kinase C, iota
GO Process (19)
GO Function (6)
GO Component (14)
Gene Ontology Biological Process
- Golgi vesicle budding [ISO]
- actin filament organization [IMP]
- cell migration [ISO]
- cell-cell junction organization [ISO]
- cellular protein localization [ISO]
- cellular response to insulin stimulus [IMP, ISO]
- establishment of apical/basal cell polarity [IMP]
- eye photoreceptor cell development [IMP]
- negative regulation of glial cell apoptotic process [ISO]
- negative regulation of neuron apoptotic process [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of endothelial cell apoptotic process [ISO]
- positive regulation of establishment of protein localization to plasma membrane [IMP]
- positive regulation of glial cell proliferation [ISO]
- positive regulation of glucose import [IMP]
- positive regulation of neuron projection development [ISO]
- protein phosphorylation [IDA, ISO]
- response to interleukin-1 [ISO]
- response to peptide hormone [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [ISO]
- Schmidt-Lanterman incisure [IDA]
- apical part of cell [IDA]
- apical plasma membrane [IDA]
- cell leading edge [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- intercellular bridge [ISO]
- microtubule cytoskeleton [ISO]
- nucleus [IDA, ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- tight junction [ISO]
Mus musculus
PREY
USP20
1700055M05Rik, AI467231, Vdu2, RP23-243I3.1
ubiquitin specific peptidase 20
GO Process (7)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein K48-linked deubiquitination [ISO]
- protein K63-linked deubiquitination [ISO]
- protein deubiquitination [IBA, ISO]
- proteolysis [ISO]
- regulation of G-protein coupled receptor protein signaling pathway [ISO]
- regulation of proteasomal protein catabolic process [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.884 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID