BAIT
PTPN23
AI462446, PTP-TD14
protein tyrosine phosphatase, non-receptor type 23
GO Process (7)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- cilium morphogenesis [ISO]
- negative regulation of epithelial cell migration [ISO]
- peptidyl-tyrosine dephosphorylation [ISO]
- positive regulation of adherens junction organization [ISO]
- positive regulation of early endosome to late endosome transport [ISO]
- positive regulation of homophilic cell adhesion [ISO]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
USP8
AI574262, AW557536, Ubpy, mKIAA0055, RP23-130L11.1
ubiquitin specific peptidase 8
GO Process (9)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
- Ras protein signal transduction [IPI]
- endosome organization [IMP, ISO]
- mitotic cytokinesis [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein K48-linked deubiquitination [ISO]
- protein K63-linked deubiquitination [ISO]
- protein deubiquitination [IDA, IMP, ISO]
- proteolysis [ISO]
- regulation of proteasomal protein catabolic process [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.775 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID