VPS4B
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- cholesterol transport [IMP]
- endosomal transport [ISO]
- endosome organization [IMP]
- endosome to lysosome transport via multivesicular body sorting pathway [ISO]
- intracellular cholesterol transport [ISO]
- negative regulation of exosomal secretion [ISO]
- positive regulation of exosomal secretion [ISO]
- positive regulation of viral release from host cell [ISO]
- potassium ion transport [IDA]
- regulation of viral process [ISO]
- response to lipid [ISO]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [ISO]
- ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [ISO]
- vacuole organization [IBA]
- viral budding via host ESCRT complex [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
VTA1
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Quantitative Score
- 0.836 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| VPS4B VTA1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| VPS4B VTA1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | Low | - | BioGRID | - |
Curated By
- BioGRID