BAIT
PKD2
C030034P18Rik, PC2, TRPP2
polycystic kidney disease 2
GO Process (37)
GO Function (21)
GO Component (21)
Gene Ontology Biological Process
- JAK-STAT cascade [IDA]
- calcium ion transmembrane transport [IDA, ISO]
- calcium ion transport [IMP, ISO]
- cell cycle arrest [IDA]
- cellular calcium ion homeostasis [IMP]
- cellular response to fluid shear stress [IMP, ISO]
- cellular response to hydrostatic pressure [ISO]
- cellular response to osmotic stress [ISO]
- cytoplasmic sequestering of transcription factor [ISO]
- detection of mechanical stimulus [IMP]
- detection of nodal flow [IMP]
- determination of left/right symmetry [IMP]
- determination of liver left/right asymmetry [ISO]
- embryonic placenta development [IMP]
- heart development [IMP]
- heart looping [ISO]
- kidney development [IGI, IMP]
- liver development [IGI]
- negative regulation of G1/S transition of mitotic cell cycle [ISO]
- negative regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- placenta blood vessel development [IMP]
- positive regulation of cell cycle arrest [ISO]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of gene expression [IMP]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [ISO]
- positive regulation of nitric oxide biosynthetic process [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- potassium ion transmembrane transport [IDA]
- regulation of cAMP metabolic process [IMP]
- regulation of calcium ion import [ISO]
- regulation of cell proliferation [ISO]
- release of sequestered calcium ion into cytosol [IMP, ISO]
- renal system development [IGI]
- renal tubule morphogenesis [IMP]
- sodium ion transmembrane transport [ISO]
- transmembrane transport [IMP]
Gene Ontology Molecular Function- ATPase binding [IPI]
- HLH domain binding [ISO]
- actinin binding [ISO]
- alpha-actinin binding [ISO]
- calcium channel activity [IDA, TAS]
- calcium ion binding [IDA]
- calcium-induced calcium release activity [ISO]
- channel activity [IMP]
- cytoskeletal protein binding [ISO]
- identical protein binding [IPI, ISO]
- ion channel binding [ISO]
- muscle alpha-actinin binding [ISO]
- phosphoprotein binding [ISO]
- potassium channel activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [IPI, ISO]
- voltage-gated calcium channel activity [ISO]
- voltage-gated cation channel activity [ISO]
- voltage-gated ion channel activity [ISO]
- voltage-gated sodium channel activity [ISO]
- ATPase binding [IPI]
- HLH domain binding [ISO]
- actinin binding [ISO]
- alpha-actinin binding [ISO]
- calcium channel activity [IDA, TAS]
- calcium ion binding [IDA]
- calcium-induced calcium release activity [ISO]
- channel activity [IMP]
- cytoskeletal protein binding [ISO]
- identical protein binding [IPI, ISO]
- ion channel binding [ISO]
- muscle alpha-actinin binding [ISO]
- phosphoprotein binding [ISO]
- potassium channel activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [IPI, ISO]
- voltage-gated calcium channel activity [ISO]
- voltage-gated cation channel activity [ISO]
- voltage-gated ion channel activity [ISO]
- voltage-gated sodium channel activity [ISO]
Gene Ontology Cellular Component
- basal cortex [IDA, ISO]
- basal plasma membrane [ISO]
- cell-cell junction [IDA]
- ciliary basal body [IDA, ISO]
- cilium [IDA, IMP]
- cytoplasm [IDA, ISO]
- cytosol [IMP]
- endoplasmic reticulum [IDA, IMP, ISO, TAS]
- endoplasmic reticulum membrane [ISO]
- extracellular vesicular exosome [ISO]
- filamentous actin [ISO]
- integral component of cytoplasmic side of endoplasmic reticulum membrane [ISO]
- integral component of lumenal side of endoplasmic reticulum membrane [ISO]
- integral component of plasma membrane [ISO]
- lamellipodium [ISO]
- membrane [ISO]
- mitotic spindle [IDA, ISO]
- motile primary cilium [IDA]
- nonmotile primary cilium [IDA]
- plasma membrane [IDA, ISO]
- polycystin complex [IDA]
Mus musculus
PREY
WNT7A
AI849442, Wnt-7a, px, tw
wingless-type MMTV integration site family, member 7A
GO Process (55)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- Wnt signaling pathway involved in wound healing, spreading of epidermal cells [ISO]
- angiogenesis [IGI]
- asymmetric protein localization [IDA]
- canonical Wnt signaling pathway [IGI, ISO]
- cartilage condensation [ISO]
- cartilage development [IDA]
- cell fate commitment [IBA]
- cell proliferation in forebrain [ISO]
- cell-cell signaling [TAS]
- central nervous system vasculogenesis [IGI]
- cerebellar granule cell differentiation [IDA]
- chondrocyte differentiation [ISO]
- dorsal/ventral pattern formation [IMP]
- embryonic axis specification [ISO]
- embryonic digit morphogenesis [ISO]
- embryonic forelimb morphogenesis [IGI, IMP, ISO]
- embryonic hindlimb morphogenesis [IGI, ISO]
- embryonic limb morphogenesis [IGI]
- establishment of cell polarity [IDA]
- forelimb morphogenesis [IMP]
- hindlimb morphogenesis [IMP]
- limb development [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of neurogenesis [ISO]
- neurotransmitter secretion [IGI]
- non-canonical Wnt signaling pathway [IGI]
- organ morphogenesis [TAS]
- oviduct development [IMP]
- palate development [ISO]
- positive regulation of JNK cascade [IBA, ISO]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cell proliferation [ISO]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of epithelial cell proliferation involved in wound healing [ISO]
- positive regulation of gene expression [IDA]
- positive regulation of receptor activity [ISO]
- positive regulation of synapse assembly [IDA, ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of axon diameter [IDA]
- regulation of axonogenesis [IDA]
- regulation of cell proliferation [IMP]
- reproductive structure development [IMP]
- response to estrogen [IMP]
- signal transduction [TAS]
- skeletal muscle satellite cell activation [IDA]
- skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [IDA]
- skeletal system morphogenesis [IMP]
- skin morphogenesis [IMP]
- somatic stem cell division [IDA]
- somatic stem cell maintenance [IMP]
- stem cell development [ISO]
- synapse organization [IGI, IMP]
- uterus development [IMP]
- uterus morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.709 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID