BAIT
CLOCK
5330400M04Rik, KAT13D, bHLHe8, mKIAA0334
circadian locomotor output cycles kaput
GO Process (19)
GO Function (14)
GO Component (7)
Gene Ontology Biological Process
- DNA damage checkpoint [ISO]
- cellular response to ionizing radiation [ISO]
- circadian regulation of gene expression [IMP, ISO]
- circadian rhythm [IDA, IMP]
- histone acetylation [IMP, ISO]
- negative regulation of glucocorticoid receptor signaling pathway [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of inflammatory response [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IC, IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- regulation of hair cycle [ISO]
- regulation of insulin secretion [IMP]
- regulation of transcription, DNA-templated [IDA, ISA]
- regulation of type B pancreatic cell development [IMP]
- response to redox state [ISO]
- spermatogenesis [IMP]
- transcription from RNA polymerase II promoter [IC]
Gene Ontology Molecular Function- DNA binding [ISO]
- E-box binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin DNA binding [IDA]
- core promoter binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- histone acetyltransferase activity [IMP, ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISA]
- transcription factor binding [ISA]
- DNA binding [ISO]
- E-box binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin DNA binding [IDA]
- core promoter binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- histone acetyltransferase activity [IMP, ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISA]
- transcription factor binding [ISA]
Gene Ontology Cellular Component
Mus musculus
PREY
WWTR1
2310058J06Rik, 2610021I22Rik, C78399, Taz
WW domain containing transcription regulator 1
GO Process (24)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IMP]
- cilium morphogenesis [IMP]
- glomerulus development [IMP]
- hippo signaling [ISO]
- kidney morphogenesis [IMP]
- mesenchymal cell differentiation [IMP]
- multicellular organism growth [IMP]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of catenin import into nucleus [ISO]
- negative regulation of fat cell differentiation [IGI]
- negative regulation of protein kinase activity [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- osteoblast differentiation [IGI, IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of epithelial to mesenchymal transition [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- protein ubiquitination [IDA]
- regulation of SMAD protein import into nucleus [ISO]
- regulation of canonical Wnt signaling pathway [IGI]
- regulation of metanephric nephron tubule epithelial cell differentiation [IGI]
- regulation of nucleic acid-templated transcription [ISO]
- regulation of transcription, DNA-templated [IDA]
- stem cell division [ISO]
Gene Ontology Molecular Function
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.746 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID