HSPA12A
Gene Ontology Cellular Component
SORL1
Gene Ontology Biological Process
- negative regulation of MAP kinase activity [ISS]
- negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [IDA, IMP]
- negative regulation of beta-amyloid formation [IDA, IMP]
- negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [IMP]
- negative regulation of neurofibrillary tangle assembly [ISS]
- negative regulation of neurogenesis [ISS]
- negative regulation of neuron death [ISS]
- negative regulation of protein binding [IDA]
- negative regulation of protein oligomerization [IMP]
- negative regulation of tau-protein kinase activity [ISS]
- positive regulation of ER to Golgi vesicle-mediated transport [IMP]
- positive regulation of choline O-acetyltransferase activity [ISS]
- positive regulation of early endosome to recycling endosome transport [IMP]
- positive regulation of endocytic recycling [IMP]
- positive regulation of protein catabolic process [IDA]
- positive regulation of protein exit from endoplasmic reticulum [IMP]
- positive regulation of protein localization to early endosome [IMP]
- post-Golgi vesicle-mediated transport [IDA]
- protein maturation [IDA]
- protein retention in Golgi apparatus [IDA]
- protein targeting [IDA, IMP]
- protein targeting to Golgi [IDA]
- protein targeting to lysosome [IDA]
- receptor-mediated endocytosis [TAS]
- regulation of smooth muscle cell migration [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- Golgi cisterna [IDA]
- early endosome [IDA, IMP]
- endoplasmic reticulum [IDA]
- endosome [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of plasma membrane [TAS]
- membrane [IDA]
- nuclear envelope lumen [IDA]
- recycling endosome [IMP]
- trans-Golgi network [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
HSPA12A targets the cytoplasmic domain and affects the trafficking of the Amyloid Precursor Protein receptor SorLA.
SorLA and Sortilin are multifunctional receptors involved in endocytosis and intracellular sorting of different and unrelated ligands. SorLA has recently attracted much attention as a novel strong risk gene for Alzheimer's disease, and much effort is currently being put into understanding the underlying molecular mechanism. Trafficking of SorLA and Sortilin are mediated by interacting with AP-1, AP-2, GGA 1-3 and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SORL1 HSPA12A | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | - | |
| SORL1 HSPA12A | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID