ABI2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NUP62
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- cell death [IMP, ISS]
- cell surface receptor signaling pathway [IDA, ISS, NAS]
- cytokine-mediated signaling pathway [TAS]
- glucose transport [TAS]
- hexose transport [TAS]
- hormone-mediated signaling pathway [NAS]
- mitotic cell cycle [TAS]
- mitotic nuclear envelope disassembly [TAS]
- negative regulation of apoptotic process [IDA, ISS]
- negative regulation of cell proliferation [IDA, ISS]
- negative regulation of programmed cell death [IDA, ISS]
- nucleocytoplasmic transport [NAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA, ISS]
- positive regulation of epidermal growth factor receptor signaling pathway [NAS]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- regulation of Ras protein signal transduction [NAS]
- regulation of glucose transport [TAS]
- regulation of signal transduction [NAS]
- small molecule metabolic process [TAS]
- transcription, DNA-templated [IDA, ISS]
- transmembrane transport [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
Identifying disease-associated missense mutations remains a challenge, especially in large-scale sequencing studies. Here we establish an experimentally and computationally integrated approach to investigate the functional impact of missense mutations in the context of the human interactome network and test our approach by analyzing ~2,000 de novo missense mutations found in autism subjects and their unaffected siblings. Interaction-disrupting de novo missense ... [more]
Throughput
- High Throughput
Additional Notes
- this interaction found to remain intact in at least one case as part of an assessment of the effect on protein-protein interactions of autism-spectrum disorder mutations in the bait proteins
- this interaction was found to remain intact in the case of at least one bait protein mutation as part of an assessment of the effect on protein-protein interactions of autism-spectrum disorder mutations in the bait proteins
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ABI2 NUP62 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID