SOX2
Gene Ontology Biological Process
- cell cycle arrest [IDA]
- chromatin organization [NAS]
- endodermal cell fate specification [IDA]
- eye development [IEP]
- forebrain development [IEP]
- glial cell fate commitment [NAS]
- inner ear development [IEP]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of epithelial cell proliferation [IDA]
- negative regulation of neuron differentiation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- neuronal stem cell maintenance [ISS]
- osteoblast differentiation [IDA]
- pituitary gland development [IEP]
- positive regulation of MAPK cascade [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- regulation of gene expression [IMP]
- regulation of transcription, DNA-templated [IDA, NAS]
- response to growth factor [IDA]
- response to wounding [IEP]
- somatic stem cell maintenance [IDA, IMP]
Gene Ontology Molecular Function
HNRNPM
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Landscape of the SOX2 protein-protein interactome.
SOX2 is a key gene implicated in maintaining the stemness of embryonic and adult stem cells that appears to re-activate in several human cancers including glioblastoma multiforme. Using immunoprecipitation (IP)/MS/MS, we identified 144 proteins that are putative SOX2 interacting proteins. Of note, SOX2 was found to interact with several heterogeneous nuclear ribonucleoprotein family proteins, including HNRNPA2B1, HNRNPA3, HNRNPC, HNRNPK, HNRNPL, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SOX2 HNRNPM | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 3539450 |
Curated By
- BioGRID