BLOC1S4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- BLOC-1 complex [IDA, ISO]
- cell [IMP]
- cytoplasm [IDA]
- intracellular [IMP]
BLOC1S6
Gene Ontology Biological Process
- anterograde axon cargo transport [IMP]
- anterograde synaptic vesicle transport [IMP]
- blood coagulation [IMP]
- endosome to melanosome transport [ISO]
- melanocyte differentiation [IMP]
- melanosome transport [ISO]
- membrane fusion [IPI]
- neuron projection development [IMP]
- pigmentation [IMP]
- positive regulation of natural killer cell activation [IMP]
- positive regulation of pigment cell differentiation [ISO]
- secretion of lysosomal enzymes [IMP]
- vesicle docking involved in exocytosis [TAS]
- vesicle fusion [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1).
Hermansky-Pudlak syndrome (HPS) is a disorder of organelle biogenesis affecting 3 related organelles-melanosomes, platelet dense bodies, and lysosomes. Four genes causing HPS in humans (HPS1-HPS4) are known, and at least 15 nonallelic mutations cause HPS in the mouse. Where their functions are known, the HPS-associated proteins are involved in some aspect of intracellular vesicular trafficking, that is, protein sorting and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BLOC1S6 BLOC1S4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID