MAP1LC3A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
LGALS3
Gene Ontology Biological Process
- eosinophil chemotaxis [IDA]
- epithelial cell differentiation [IEP]
- innate immune response [TAS]
- macrophage chemotaxis [IDA]
- monocyte chemotaxis [IDA]
- mononuclear cell migration [IDA]
- negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [ISS]
- negative regulation of T cell receptor signaling pathway [ISS]
- negative regulation of endocytosis [IDA]
- negative regulation of extrinsic apoptotic signaling pathway [IDA]
- negative regulation of immunological synapse formation [ISS]
- neutrophil chemotaxis [IDA]
- positive chemotaxis [IDA]
- positive regulation of calcium ion import [IDA]
- positive regulation of mononuclear cell migration [IDA]
- regulation of T cell apoptotic process [IDA]
- regulation of T cell proliferation [IMP]
- regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Alpha-synuclein fibrils recruit TBK1 and OPTN to lysosomal damage sites and induce autophagy in microglial cells.
Autophagic dysfunction and protein aggregation have been linked to several neurodegenerative disorders, but the exact mechanisms and causal connections are not clear and most previous work was done in neurons and not in microglial cells. Here, we report that exogenous fibrillary, but not monomeric, alpha-synuclein (AS, also known as SNCA) induces autophagy in microglial cells. We extensively studied the dynamics ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LGALS3 MAP1LC3A | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | - |
Curated By
- BioGRID